Chronic Leukaemia Flashcards Preview

Haematology > Chronic Leukaemia > Flashcards

Flashcards in Chronic Leukaemia Deck (29):
1

what is CML

clonal myeloproliferative disorder- incr in neutrophils in peripheral blood, increased cellularity of the marrow

2

what is the chromosome in CML

Philadelphia. BCR-ABLE1. translocation t(9,22)

3

what cell is increased in CML

neutrophils

4

what happens in blast transformation

may transform from relatively stable chronic phase to acute leukaemia phase

5

clinical features CML

at all ages peak 25-45. weight loss, night sweats, itching, left hypochondrial pain, gout. splenomegaly

6

what can hyperviscosity cause in CML

priapism, visual disturbance, headaches

7

lab findings CML

raised WCC, anaemia may be present, platelets can do anything, raised uric acid. hypercellular BM

8

what is the course of CML

most patients are well in chronic phase, death is from transformation to acute leukaemia

9

what % of blast transformation in CML is to AML

80% (20 to ALL)

10

what drug can be given for incr WCC

hydroxycarbamide

11

treatment CML

imatinib- tyrosine kinase inhibitor

12

what is given to prevent hyperuricaemia

allopurinol

13

what can be used to treat CML if patient doesn't respond

allogeneic stem cell transplant

14

therapy for acute phase CML

as for AML and ALL with tyrosine inhibitor. but prognosis is poor

15

what is CLL

lymphoproliferative disorder. B cell clonal disease. lymphocytes accumulate in blood, bone marrow, lymph nodes, spleen

16

what is the most common leukaemia in the west

CLL

17

what is stage dependent on in CLL

extent of lymphadenopathy

18

stage A CLL

19

stage B CLL

>3 lymphoid areas involved.

20

stage C CLL

anaemia and thrombocytopenia present

21

features stages B and C CLL

lymphadenopathy- symmetrical, painless), night sweats, weight loss, symptoms from bone marrow failure

22

lab findings CLL

incr blood lymphocytes.

23

favourable prognostic features CLL

female, stage A, lymphocyte doubling time >1y, AIHA absent

24

what is Richters syndrome

local lymphoblastic transformation in CLL- poor prognosis

25

treatment for stage A patients CLL

observation for asymptomatic patients

26

treatments for stage B and C CLL

fludarabine, cyclophosphoramide, ritixumab

27

what can you give for bone marrow failure

corticosteroids

28

what can be used in late stage CLL

alemtuzumab. splenectomy

29

what is prolymphocytic leukaemia

resembles CLL but occurs in older patients, WCC high, poor response to treatment