Pancytopenia and bone marrow failure Flashcards Preview

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Flashcards in Pancytopenia and bone marrow failure Deck (20):
1

what is pancytopenia

reduction in all cell lines

2

what is pancytopenia

reduction in all cell lines

3

causes of pancytopenia

decr marrow production- aplastic anaemia, infiltration- acute leukaemia, myelodysplasia, myeloma, lymphoma, TB; megaloblastic anaemia, myelofibrosis. incr peripheral destruction- hypersplenism

4

agranulocytosis

decr white cells- increased susceptbility to infection

5

aplastic anaemia

pancytopenia and hypoplastic marrow- marrow stops making cells.

6

what does aplastic anaemia present with

features of anaemia, infection, bleeding

7

causes aplastic anaemia

autoimmune, drugs, irradiation, inherited- Fanconi

8

treatment aplastic anaemia

support bone marrow. bone marrow transplant from HLA matched sibling. immunosuppression

9

when are platelets indicated

10

when are platelets indicated

11

causes of pancytopenia

decr marrow production- aplastic anaemia, infiltration- acute leukaemia, myelodysplasia, myeloma, lymphoma, TB; megaloblastic anaemia, myelofibrosis. incr peripheral destruction- hypersplenism

12

agranulocytosis

decr white cells- increased susceptbility to infection

13

aplastic anaemia

pancytopenia and hypoplastic marrow- marrow stops making cells.

14

what does aplastic anaemia present with

features of anaemia, infection, bleeding

15

causes aplastic anaemia

autoimmune, drugs, irradiation, inherited- Fanconi

16

treatment aplastic anaemia

support bone marrow. bone marrow transplant from HLA matched sibling. immunosuppression

17

what occurs in marrow support

red cell transfusion, platelets, neutrophils

18

when are platelets indicated

19

what is the aspirate for

provides a film

20

what is the trephine for

core of bone allows assessment bone marrow cellularity, architecture, presence infiltrative disease