Chronic Myeloid Leuk Flashcards
1
Q
Defin
A
Clonal prolif myeloid cells.
15% of leuks
40-69 yo.
Rare as kid.
2
Q
Px
A
Chronic and insidious Wl Tired Fever Sweat Gout Bleeding Abo discomf, hepatosplenomeg Anaemia Bruising
3
Q
Investig
A
WCC often high an all myeloid cells high
Hb low or norm
Pl variable
Urate and b12 high
4
Q
Mx
A
Imatinib bcr-abl tyr kinase inhibitor
More potent 2nd gen egs dasatinib
Hydroxycarbamide
Allogenic SC transpl HLA matched.
