Haemophilia A

Question 1

Defin

Answer 1

Fac VIII defic.
X linked recss gene inversion.
Male only.

Question 2

Px

Answer 2

Often after surg or trauma.
Arthropathy due to bleed into joints
Muscle haematomas- can cause N palsy and compartm synd.

Question 3

Investig

Answer 3

Incr APTT

Low fac VIII

Question 4

Mx

Answer 4

No NSAIDs or IM injec. 
Press and elevat for minor bleeds
Desmopressin incrs fac VIII
Recombin fac VIII
Genetic counselling