Citric Acid Cycle<3 Flashcards
(21 cards)
what do most fuels enter the CAC as?
Acetyle coenzyme A
CAC is the final common pathway for what?
oxidation of fuel molecules e.g., fatty acids and amino acids
where does the CAC take place?
mitrocondria
what is the completion of the CAC?
completion from glucose in the cytoplasm to end products of metabolism -> E generation, CO2 and water
what does the CAC start with?
complete oxidation of glucose derivatives
the most ATP is generated from what?
aerobic processing of glucose
what does the CAC harvest
high energy electrons
what are fuel molecules?
C-compounds capable of being oxidised
pyruvate generated from glucose is ——— ———- to form ———
OXIDATIVLEY DECARBOYLATED to form ACETYLE COA
what is the CAC
gateway to aerobic metabolism
what is the purpose of the CAC
to harvest high energy electrons from carbon fuels
the electrons removed from acetylCoA are used to form what?
NADH and FADH2 (electron carriers)
what are NADH and FADH2
electron carriers
how many molecules of ATP are yielded when the e- carriers are oxidised by oxygen in oxidative phosphorylation
9
when are these electrons released?
in the deoxidation of NAHD and FADH2.
once the e-have been released what do they do?
flow through a series of membrane proteins (e- transport chain)
to transform pyruvate to AcetyleCoA it require what?
3 enzymes of pyruvate dehydrogenase and 5 coenzymes i.e. FAD
when acetylecoa is oxidised into CO2 what does it generate? and what can these do?
high energy e-
they can power synthesis of ATP
what can the defects in the CAC contribute to?
cancer
net reaction of CAC?
acetylecoA + 3NAD+ +FAD + ADP + Pi + CoA–>
2CO2+ 3NADH + FADH2 + ATP +2H+ +CoA
disruption of pyruvate metabolism can be the cause of?
beriberi poisoning (an arsnic poisoning)
