Class/Drugs/Mechanisms/Side Effects Flashcards Preview

CV PHARM...Intro to CV Pharmacology > Class/Drugs/Mechanisms/Side Effects > Flashcards

Flashcards in Class/Drugs/Mechanisms/Side Effects Deck (30)
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1

a1 antagonists drugs

all end in "osin"
"azosins"

2

a1 antagonists mechanism

block a1 receptors on arterioles and venules

3

a1 antagonists side effects/notes

orthostatic hypotension!!!!
(and fainting...esp on first dose)

4

a2 agonist drugs

Clonidine

Methyldopa

5

a2 agonist mechanism

decrease sympathetic outflow by stimulating CNS receptors (dropping CO and BP)

6

a2 agonist side effects/notes

Clonidine...
--Rebound HTN!!! if drug suddenly stopped
--dry mouth
--sedation
--bradyarrhythmias

Methyldopa...
--sedation
--Positive coombs test
--prodrug converted to a-methyl-NE

7

beta-blockers drugs

"olols"
if different, has additional action

8

beta-blockers mechanism

block post-synaptic b-receptors

9

beta-blockers side effects/notes

CV disturbances
impotence
asthma

If lipophilic (crosses blood-brain barrier)...
--sleep disturbances
--sedation

10

post-ganglionic sympathetic terminal blocker drugs

Reserpine

11

post-ganglionic sympathetic terminal blocker mechanism

Destroys adrenergic synaptic vesicles
-->depleting NE and decreasing release

12

post-ganglionic sympathetic terminal blocker side effects/notes

rarely used
depression
sedation
dry mouth
edema
bradycardia
night terrors (crosses blood-brain barrier)

13

Ganglionic blocker drugs

Hexamethonium
Trimethaphan

14

Ganglionic blocker mechanism

Ganglionic nicotinic antagonists that inhibit post-ganglionic sympathetic neurons

15

Ganglionic blocker side effects/notes

Rarely used
Both sympathetic and parasympathetic blocked!!

16

Calcium channel blocker Drugs

dihydropyridines
("Pines")

non-dihydropyridines
(Diltiazem, Verapamil)

17

Dihydropyridines Mechanism

block L-type Calcium channels in smooth muscle

JUST VASCULAR ACTION!!!!!!

18

Non-dihydropyridines mechanism

Block L-type Calcium channels in CARDIAC AND smooth muscle

Vascular AND heart action!!!!!

19

Calcium channel blockers side effects/notes

constipation
edema
headache
bradycardia
GI disturbances
dizziness
AV block (non-dihydro...)
tachycardia (non-dihydro...)

20

Drugs acting through NO

Hydralazine
Nitroprusside

21

Drugs acting through NO mechanism

release endothelial NO
stimulate guanylate cyclase-->increase cGMP

22

Hydralazine side effects/notes

reversible SLE-like syndrome
edema
arteriolar dilation

23

Nitroprusside

For hypertensive emergencies
arteriolar and venous dilation
cyanide poisoning

24

Drugs opening K channels

Minoxidil
Diazoxide

25

Drugs opening K channels...MOA

open K channels-->hyperpolarization of VSM

26

Minxidil side effects/notes

for severe HTN
hirsutism
pericardial effusion
edema

27

Diazoxide side-effects/notes

For HT emergencies
hypoglycemia

28

D1 agonists

Fenoldopam

29

D1 agonist MOA

vasodilates renal vessels

30

D1 agonists notes

for HT emergencies