Treatment of HTN Flashcards Preview

CV PHARM...Intro to CV Pharmacology > Treatment of HTN > Flashcards

Flashcards in Treatment of HTN Deck (25)
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1

ACEIs...drugs

"prils"

2

ACEIs...MOA

blocks formation of Ang II-->decrease in aldosterone

3

ACEIs...side effects/notes

(b/c increase in bradyokinin...) Cough!!!
hyperkalemia
angioedema
renal damage in pre-existing renal disease
***contraindicated in pregnancy

4

ARBs...drugs

"Sartans"

5

ARBs...MOA

Block Ang II at AT receptor--> decrease in aldosterone

6

ARBs...side effects

renal damage in pre-existing renal disease
hyperkalemia
**contraindicated in pregnancy

7

Renin inhibitor...drug

Aliskerin

8

Renin inhibitor...MOA

Decrease Ang I and therefore Ang II and aldosterone

9

Renin inhibitor...side effect

hyperkalemia

10

Thiazides...notes

useful in mild HTN

decrease K, Mg, Na

increase Ca, uric acid, glucose, LDL cholesterol, TGs

11

Loops...Notes

useful in moderate-severe HTN

decrease K, Mg, Ca, Na

increase uric acid, glucose, LDL cholesterol, TGs

12

Aldosterone antagonists...notes

Hyperkalemia
metabolic acidosis
gynecomastia
safe for use during pregnancy

13

Treatment of HTN during...
Pregnancy
GOOD!!!

alpha-methyldopa
hydralazine

14

Treatment of HTN during...
Pregancy
BAD!!!!

ACEIs and ARBs

15

Treatment of HTN during...
Diabetes
GOOD!!!!

ACEIs and ARBs

diuretics also good 2nd line agents

16

Treatment of HTN during...
Diabetes
BAD!!!!

b-blockers (high doses)

add-on use in low doses

17

Treatment of HTN during...
Heart failure
GOOD!!!!

ACEIs

ARBs, diuretics (all classes)
select CCBs (amlodipine, felodipine)

18

Treatment of HTN during...
Heart Failure
BAD!!!!!

B-blockers (high doses)
Verapamil
diltiazem



Add-on use w/ low dose BBs

19

Treatment of HTN during...
COPD/asthma
GOOD!!!!

Calcium Channel Blockers

20

Treatment of HTN during...
COPD/asthma
BAD!!!!!

non-selective b-blockers (high dose)

ACEIs (b/c chronic cough)

21

Treatment of HTN during...
CKD
GOOD!!!!

ACEIs and ARBs
Loop diuretics (don't use others w/ renal insufficiency)

22

Treatment of HTN during...
BPH
Good!!!

alpha-blockers

23

Treatment of HTN during...
Severe depression
BAD!!!!!

B-blockers
reserpine
alpha-methyldopa

24

Treatment of HTN during...
Post MI
GOOD!!!

B-blockers
spironolactone
cardiac CCBs

ACEIs

25

Treatment of HTN during...
prophylaxis of recurrent stroke
GOOD!!!!

Diuretics
ACEIs