Treatment of HTN Flashcards
(25 cards)
ACEIs…drugs
“prils”
ACEIs…MOA
blocks formation of Ang II–>decrease in aldosterone
ACEIs…side effects/notes
(b/c increase in bradyokinin…) Cough!!!
hyperkalemia
angioedema
renal damage in pre-existing renal disease
***contraindicated in pregnancy
ARBs…drugs
“Sartans”
ARBs…MOA
Block Ang II at AT receptor–> decrease in aldosterone
ARBs…side effects
renal damage in pre-existing renal disease
hyperkalemia
**contraindicated in pregnancy
Renin inhibitor…drug
Aliskerin
Renin inhibitor…MOA
Decrease Ang I and therefore Ang II and aldosterone
Renin inhibitor…side effect
hyperkalemia
Thiazides…notes
useful in mild HTN
decrease K, Mg, Na
increase Ca, uric acid, glucose, LDL cholesterol, TGs
Loops…Notes
useful in moderate-severe HTN
decrease K, Mg, Ca, Na
increase uric acid, glucose, LDL cholesterol, TGs
Aldosterone antagonists…notes
Hyperkalemia
metabolic acidosis
gynecomastia
safe for use during pregnancy
Treatment of HTN during…
Pregnancy
GOOD!!!
alpha-methyldopa
hydralazine
Treatment of HTN during…
Pregancy
BAD!!!!
ACEIs and ARBs
Treatment of HTN during…
Diabetes
GOOD!!!!
ACEIs and ARBs
diuretics also good 2nd line agents
Treatment of HTN during…
Diabetes
BAD!!!!
b-blockers (high doses)
add-on use in low doses
Treatment of HTN during…
Heart failure
GOOD!!!!
ACEIs
ARBs, diuretics (all classes) select CCBs (amlodipine, felodipine)
Treatment of HTN during…
Heart Failure
BAD!!!!!
B-blockers (high doses)
Verapamil
diltiazem
Add-on use w/ low dose BBs
Treatment of HTN during…
COPD/asthma
GOOD!!!!
Calcium Channel Blockers
Treatment of HTN during…
COPD/asthma
BAD!!!!!
non-selective b-blockers (high dose)
ACEIs (b/c chronic cough)
Treatment of HTN during…
CKD
GOOD!!!!
ACEIs and ARBs Loop diuretics (don't use others w/ renal insufficiency)
Treatment of HTN during…
BPH
Good!!!
alpha-blockers
Treatment of HTN during…
Severe depression
BAD!!!!!
B-blockers
reserpine
alpha-methyldopa
Treatment of HTN during…
Post MI
GOOD!!!
B-blockers
spironolactone
cardiac CCBs
ACEIs
