Digoxin Flashcards Preview

CV PHARM...Intro to CV Pharmacology > Digoxin > Flashcards

Flashcards in Digoxin Deck (7)
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1

Na/K ATPase inhibition-->

intracellular increase in Na and decrease in K-->

2

activation of Na/Ca exchanger-->

increase in Ca--> decreased cellular polarization

3

increase in intracellular Ca (effect on myocardium)

inotropic effect-->
increased CO-->decreased sympathetic tone---->Vasodilation

4

increase in intracellular Ca (effect on VSM tone)

increased VSM tone
vasoconstriction

5

Digoxin pks

very narrow therapeutic window

6

Important digoxin side effects

visual disturbances!!! (halo)

7

Digoxin antidote

Digibind