First step in AB selection?
- ID specific site - Localize the source, first step in defining spectra
What determines the microbial spectrum?
The site of infection
What should be considered when determining a microbial spectrum?
- Host comorbidity (HIV)
Considerations when determining drug route?
- Host Immunity
What should be considered when assessing drug benefit/toxicity?
- Host immunity
- Host PMHx
- Host comorbidity
What are empirical AB selection principles driven by?
- Likelihood of resistance
- Severity of illness
What drives definitive selection of AB?
- Culture results
In a patient with adrenal insufficiency, why would a fever be observed?
Taking the patient off steroids results in fever
What are the most likely bugs to cause infection of skin?
- Staphylococcus aureus
When considering a possible staph infection, what important consideration should be made?
Is it methicillin resistant or not? (MRSA vs. MSSA)
If staphylococcus aureus infection is ID'ed, what is the plan?
Use IV ABs because of the potential of endocarditis