Antibiotics I Flashcards Preview

Pharmacology Unit 6 > Antibiotics I > Flashcards

Flashcards in Antibiotics I Deck (11)
Loading flashcards...
1


Relationship b/w therapeutic index and bugs


The width of Tx index is directly proportional to the uniqueness of the microbial target

2


What is the relationship b/w microbial target and likelihood to cause allergy?


The uniqueness of the microbial target is proportional to the likelihood for the AB to cause allergy

3


How are AB initially selected for in the clinical setting?


Choice baseed on the likely organism causing the infection in a specific organ.

4

What are the general cell wall synthesis inhibitors?

 

  • Lactams
  • Cephalosporins
  • Glycopeptides

5


What are the general cell membrane toxins?

 

  • Cyclic lipopeptide (daptomycin)
  • Polymixins (colistin)

6


What are the inhibitors of nucleic acid synthesis?

 

  • Fluoroquinolones - 1st and 2nd generation
  • Rifampin
  • Metronidazole

7


What are the inhibitors of protein synthesis organized by ribosomal unit?

 

  • 30S inhibitors - aminoglycosides, tetracyclines
  • 50S inhibitors - macrolides, linezolid, clindomycin

8


What are the Bacterial antimetabolites?

 

  • Folic acid trimethoprim/sulfamethoxazole
  • Antituberculars

9


What antiviral agents treat DNA viruses?

 

  • Nucleoside analogs for HSV/VZV
  • Nucleoside analogs for CMV
  • Pyrophosphate analog for HSV/VZV/CMV

10


What agents are used to treat RNA viruses?

 

  • Neuraminidase inhibitors for influenza A and B
  • Nucleoside reverse transcriptase inhibitors for HIV/HBV
  • Non-nucleoside reverse transcriptase inhibitors for HIV
  • Protease inhibitors for HIV
  • Protease inhibitors for HCV
  • Other for HIV

11


What are the strategies for antifungal drugs?

 

  • Cell wall synthesis inhibitors
  • Cell membrane inhibitors
  • Inhibition of nucleic acid synthesis by a nucleoside analog