What is the animal-plant warfare hypothesis?
Each developed mechanisms to protect self from other species
Plants - poisons
Humans - Mechanisms to detox self
What is the typical course of metabolism of drugs?
Phase I using Cytochrome P450 3A
What type of polymorphisms typically have clincally relevant effects?
Polymorphisms in transporters and drug metabolizing enzymes
Why are polymorphisms in drug targets typically clinically irrelevant?
There is no clinical effect because the targets are so highly preserved
What are toxicity targets and why are they clinically relevant?
Toxicity targets are targets that result in adverse effects for a patient. Drugs w/i a class have varying affinities for these toxicity targets.