Clinical Case Discussion - Pharmacogenetics Flashcards Preview

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Flashcards in Clinical Case Discussion - Pharmacogenetics Deck (5)
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1

What is the animal-plant warfare hypothesis?


Each developed mechanisms to protect self from other species

Plants - poisons

Humans - Mechanisms to detox self

2

What is the typical course of metabolism of drugs?


Phase I using Cytochrome P450 3A

3


What type of polymorphisms typically have clincally relevant effects?


Polymorphisms in transporters and drug metabolizing enzymes

4

Why are polymorphisms in drug targets typically clinically irrelevant?


There is no clinical effect because the targets are so highly preserved

5

What are toxicity targets and why are they clinically relevant?


Toxicity targets are targets that result in adverse effects for a patient. Drugs w/i a class have varying affinities for these toxicity targets.