Clinical Case Discussion - Pharmacogenetics Flashcards Preview

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Flashcards in Clinical Case Discussion - Pharmacogenetics Deck (5)
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What is the animal-plant warfare hypothesis?

Each developed mechanisms to protect self from other species

Plants - poisons

Humans - Mechanisms to detox self


What is the typical course of metabolism of drugs?

Phase I using Cytochrome P450 3A


What type of polymorphisms typically have clincally relevant effects?

Polymorphisms in transporters and drug metabolizing enzymes


Why are polymorphisms in drug targets typically clinically irrelevant?

There is no clinical effect because the targets are so highly preserved


What are toxicity targets and why are they clinically relevant?

Toxicity targets are targets that result in adverse effects for a patient. Drugs w/i a class have varying affinities for these toxicity targets.