Clinical Pharmacology and Therapeutics Flashcards Preview

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Flashcards in Clinical Pharmacology and Therapeutics Deck (19)
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1

Cyclophosphamide MoA

T cell modulation

2

Adalimumab MoA

TNF alpha other TNF alpha golimumab used in psoriasis/psoriatic arthropathy

3

Trimethoprim effect on kidney

Can temporarily raise creatinine

4

Ciclosporin MoA

IL-2 production inhibitor

5

Notable side effect of tramadol

Serotonin syndrome

6

Primary mode of action of digoxin

intracellular sodium accumulation -> this in turn then pumps more calcium in in exchange for sodium which promotes myocardial contractility

7

MoA vincristine

mitotic inhibition -> acts on metaphase

8

COCP increases risk of which cancer?

Cervical cancer risk increased until about 10 years from moment that pill is stopped

9

Second dose of amiodarone in pulseless VT

150mg once five cycles of CPR done, first dose of 300mg given but still in pulseless VT

10

ACEi in pregnancy

Associate with birth defects -> stop and observe BP, start labetalol or methyldopa

11

Treatment secondary hypoparathyroidism

12

What is cinacalcet? 

13

side effects of gold (smae as mtx)

pancytopenia and pulmonary fibrosis

14

SE of hydroxychloroquine

nausea and retinopathy rarely

15

THings to bare in mind with ribavirin treatment

Haemolytic anameia (drop of 20 points) so avoid in elderly.

Teratogenic so conception for 1 year after 

SE of interferon therapy is flu like sx, emotional liability, mood changes and thyroiditis

16

Which drugs cause drug induced lupus?

17

MoA antiplatelets drugs

18

Theophylline OD sx and tx

Severe nausea and vomiting, seizures, myoclonus, hyperthermia, myoclonus, rhabdomyolysisis and AKI. use multi-dose activated charcoal 

19

Co-trimoxazole side effect

allergic mycoarditis