CNS Stimulant Drugs Flashcards
ADHD Drug Legal Considerations
Stimulants and Non-Stimulants
Stimulants:
Controlled Substances
No more than 1 month prescriptions with no refills
Non-Stimulants:
Not Scheduled
Prescriptions up to 1 year
Atomoxetine
General Classification, Formulation, Mechanism of Action
Non-Stimulant ADHD drug
Capsule
Decreased presynaptic NE uptake
Anti-Hypertensive Non-Stimulant ADHD Drugs
Examples (2), Formulation and Mechanism of Action
Guanfacine
Clonidine
Tablet
CNS alpha-2 agonists
Stimulant Drug Common Side Effects (8)
GI Distress Headache Decreased Appetite (stunts growth) Insomnia Anxiety Irritability Psychosis Elevated BP/HR
Stimulant Drug Rare Side Effects (6)
Priapism Seizure Sudden Cardiac Death Stroke MI Chemical Leukoderma
Immediate Release Amphetamine Based Stimulants
Trade and Generic Names (4) with Formulations
Adderall, Dextroamphetamine, Tablet
ProCentra, Dextroamphetamine Sulfate, Liquid
Evekeo, Amphetamine Sulfate, Capsule
Zenzidi, Dextroamphetamine, Tablet
Extended Release Amphetamine Based Stimulants
Trade and Generic Names (5) with Formulations
Adderall XR, Dextroamphetamine, Capsule
Dexedrine, Dextroamphetamine, Capsule
Dyanavel XR, Amphetamine, Liquid
Vyvanse, Lisdexamfetamine, Capsule (prodrug)
Mydayis, Amphetamine, Capsule
Adzenys-XR
Generic Drug, Formulation, % of Extended/Immediate
Amphetamine
Oral Dissolving Tablet
50% XR and 50% IR
Immediate Release Methylphenidate Based Stimulants
Trade and Generic Names (3) with Formulations
Focalin, Dexmethylphenidate, Tablet
Methylin, Methylphenidate, Liquid
Ritalin, Methylphenidate, Tablet
Sustained Release Methylphenidate Based Stimulants
Trade and Generic Names (2) with Formulations
Ritalin-SR, Methylphenidate, Tablet
Desoxyn, Methamphetamine, Tablet
Extended Release Methylphenidate Based Stimulants
Trade and Generic Names
Tablet (2) Transdermal Patch (1), Chewable (1) Liquid (1)
Tablet Formulations:
Concerta, Methylphenidate HCl
Comtempla XR-ODT, Methylphenidate ER
Transdermal Patch:
Daytrana, Methylphenidate
Chewable Tablets:
Quillichew, Methylphenidate HCl
Liquid:
Quillivant XR, Methylphenidate
Extended Release Methylphenidate Based Stimulants
Trade and Generic Names
Capsule Formulations (4)
“FARM”
Focalin XR, Dexmethylphenidate HCl
Aptensio XR, Methylphenidate
Ritalin LA, Methylphenidate HCl ER
Metadate CD, Methylphenidate HCl
Stimulant Medication Mechanisms of Action
Methylphenidate (1), Amphetamines (2), Lisdexamfetamine (3) D Isomers (1)
Methylphenidate: Blocks reuptake of NE, DA and 5-HT
Amphetamines:
Block NE/DA/5-HT reuptake
Increase NE/DA/5-HT release via VMAT
Lisdexamfetamine:
Pro-drug
Inhibits reuptake
Stimulates release
D isomers of MPH/AMP have more CNS activity than L isomers
