CNS Stimulant Drugs Flashcards Preview

Neuro Muscular Psych Block 1 > CNS Stimulant Drugs > Flashcards

Flashcards in CNS Stimulant Drugs Deck (13)
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1

ADHD Drug Legal Considerations
Stimulants and Non-Stimulants

Stimulants:
Controlled Substances
No more than 1 month prescriptions with no refills

Non-Stimulants:
Not Scheduled
Prescriptions up to 1 year

2

Atomoxetine
General Classification, Formulation, Mechanism of Action

Non-Stimulant ADHD drug

Capsule

Decreased presynaptic NE uptake

3

Anti-Hypertensive Non-Stimulant ADHD Drugs
Examples (2), Formulation and Mechanism of Action

Guanfacine
Clonidine

Tablet

CNS alpha-2 agonists

4

Stimulant Drug Common Side Effects (8)

GI Distress
Headache
Decreased Appetite (stunts growth)
Insomnia
Anxiety
Irritability
Psychosis
Elevated BP/HR

5

Stimulant Drug Rare Side Effects (6)

Priapism
Seizure
Sudden Cardiac Death
Stroke
MI
Chemical Leukoderma

6

Immediate Release Amphetamine Based Stimulants
Trade and Generic Names (4) with Formulations

Adderall, Dextroamphetamine, Tablet

ProCentra, Dextroamphetamine Sulfate, Liquid

Evekeo, Amphetamine Sulfate, Capsule

Zenzidi, Dextroamphetamine, Tablet

7

Extended Release Amphetamine Based Stimulants
Trade and Generic Names (5) with Formulations

Adderall XR, Dextroamphetamine, Capsule

Dexedrine, Dextroamphetamine, Capsule

Dyanavel XR, Amphetamine, Liquid

Vyvanse, Lisdexamfetamine, Capsule (prodrug)

Mydayis, Amphetamine, Capsule

8

Adzenys-XR
Generic Drug, Formulation, % of Extended/Immediate

Amphetamine

Oral Dissolving Tablet

50% XR and 50% IR

9

Immediate Release Methylphenidate Based Stimulants
Trade and Generic Names (3) with Formulations

Focalin, Dexmethylphenidate, Tablet

Methylin, Methylphenidate, Liquid

Ritalin, Methylphenidate, Tablet

10

Sustained Release Methylphenidate Based Stimulants
Trade and Generic Names (2) with Formulations

Ritalin-SR, Methylphenidate, Tablet

Desoxyn, Methamphetamine, Tablet

11

Extended Release Methylphenidate Based Stimulants
Trade and Generic Names
Tablet (2) Transdermal Patch (1), Chewable (1) Liquid (1)

Tablet Formulations:
Concerta, Methylphenidate HCl
Comtempla XR-ODT, Methylphenidate ER

Transdermal Patch:
Daytrana, Methylphenidate

Chewable Tablets:
Quillichew, Methylphenidate HCl

Liquid:
Quillivant XR, Methylphenidate

12

Extended Release Methylphenidate Based Stimulants
Trade and Generic Names
Capsule Formulations (4)

“FARM”

Focalin XR, Dexmethylphenidate HCl

Aptensio XR, Methylphenidate

Ritalin LA, Methylphenidate HCl ER

Metadate CD, Methylphenidate HCl

13

Stimulant Medication Mechanisms of Action
Methylphenidate (1), Amphetamines (2), Lisdexamfetamine (3) D Isomers (1)

Methylphenidate: Blocks reuptake of NE, DA and 5-HT

Amphetamines:
Block NE/DA/5-HT reuptake
Increase NE/DA/5-HT release via VMAT

Lisdexamfetamine:
Pro-drug
Inhibits reuptake
Stimulates release

D isomers of MPH/AMP have more CNS activity than L isomers