Opioid Drugs Flashcards Preview

Neuro Muscular Psych Block 1 > Opioid Drugs > Flashcards

Flashcards in Opioid Drugs Deck (14)
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1

Opioid Agonist Examples (9)

Oxycodone
Hydrocodone
Morphine
Hydromorphine
Methadone
Meperidene
Fentanyl
Codeine
Propoxyphene

2

Partial Opioid Agonist Examples (4)

Buprenorphine
Butorphanol
Pentazocine
Nalbuphine

3

Opioid Antagonist Examples (2)

Naloxone
Naltrexone

4

General Opioid Drugs
Mechanism of Action and Black Box Warning

Bind opioid receptors in CNS causing inhibition of ascending pain pathways

Life threatening respiratory depression possible in case of overdose

5

Indications of Opioid Use
Primary (7) and Additional (5)

Myocardial Infarction
Sickle cell Crisis
Post-Operative
Kidney Stones
Trauma
Cancer
Low Back Pain

Adjunct to general anesthesia
Epidural anesthesia
Palliative care
Antitussive
Antidiarrheal (Loperamide)

6

Opioid Receptors
Subtypes (3) with Endogenous Peptide Affinities (3)

Mu: Endorphin > Enkephalin > Dynorphin

Delta: Enkephalin > Endorphin and Dynorphin

Kappa: Dynorphin >> Endorphin and Enkephalin

7

Opioid Physiologic Effects
Stimulant (2) and Depressant (4)

Stimulates:
Antinociceptive system (analgesic)
Bowel smooth muscle (spastic constipation)

Dampens:
Pain sensation (analgesia)
Mood alertness
Respiratory center
Cough center (antitussive)

8

Opioid Drug Acute Adverse Effects (7)

Respiratory depression
Nausea/Vomiting
Constipation
Urinary Retention
Sedation
Delirium
Seizures

9

Opioid Drug Chronic Adverse Effects (5)

Hypogonadism
Immunosuppression
Withdrawal
Tolerance/Dependence/Addiction
Hyperalgesia

10

Opioid Drug Interactions
Examples with Specific Reaction (3)

Sedative-Hypnotics:
Increased respiratory depression

Antipsychotics:
Increased sedation and CV depression

Monoamine Oxidase Inhibitors:
Hyperpyrexic coma and hypertension

11

Naloxone
Mechanism of Action, Indication, Adverse Effect

Pure opioid antagonist

Reversal of opioid overdose

Acute opioid withdrawal via catecholamine release

12

Naltrexone
Mechanism of Action (2) Indications (2) Adverse Effects (2)

Pure competitive opioid antagonist, especially at mu receptors

Alcohol use disorder
Opioid dependence

Opioid overdose from decreased tolerance
Acute Opioid Withdrawal: Pain, HTN, Sweating, Agitation

13

Morphine Sulfate
Mechanism of Action, Contraindications (3) Adverse Effects (5)

Opioid agonist

Asthma
Respiratory depression
Sulfa allergy

Sedation
Lightheaded
Dizzy
N/V
Constipation

14

Buprenorphine
Mechanism of Action, Indication, Drug Interaction, Adverse Effects (7)

Partial Opioid Agonist/Antagonist

Treatment of opioid dependence

CYP3A4 inhibitors

Headache
N/V
Hyperhidrosis
Constipation
Withdrawal
Insomnia
Pain