Coagulation / Bleeding Disorders Flashcards
What type of vessels use primary hemostasis the most?
arteries
What type of vessels use secondary hemostasis the most?
veins
i.e: DVT
Platelet function assay
another name for closure time
measures how long for primary hemostasis to form platelet plug in test tube
vWF antigen vs. activity
antigen is more specific
low vWF antigen and activity can mean vWD
Ristocetin co-factor
another term for vWF activity
Type I vWD
reduced vWF number but it functions correctly overall
thrombocytopenia
low platelet count
What is common signs of thrombocytopenia?
purpura and petechiae
what is there a risk of with Thrombocytopenia?
spontaneous bleeding due to lack of platelets
high risk of bleeding thrombocytopenia values
<10,000
low risk of bleeding thrombocytopenia values
<20,000
Immune Thrombocytopenic Purpura
viral infection causes an immune response against platelets
Immune Thrombocytopenic Purpura treatment
platelet transfusion will not work as antibodies will just degrade them
need immunosuppression or splenectomy
problem with platelets = primary hemostasis problem
What conditions cause thrombocytopenia by increased consumption of platelets?
DIC, HUS, Heparin Induced Thrombocytopenia
What specifically does aspirin affect?
aspirin = antiplatelet
prevents step 2 of primary hemostasis (no degranulation of platelets)
COX1 and platelets
aspirin activates COX1 which releases prostaglandins
prostaglandins prevent platelet granulation release
what type of bleeding indicates primary hemostasis?
mucosal
what type of bleeding indicates secondary hemostasis?
deep / joint
for secondary hemolysis, what labs are checked next?
PT and PTT
then mixing studies
why are platelets seen more in the arteries?
platelets are more stable in that higher pressure system
what is the primary tests for primary hemostasis?
vWF and ITP
*looking for a platelet problem
what are the vitamin K dependent factors?
2, 7, 9, 10
What 2 things should you think about if both PTT and PT are delayed?
fibrinogen or vitamin K def.
common pathway problem
hemarthrosis
swollen, hot joint
common in hemophilia patients
