coagulation cascade Flashcards
primary hemostasis (3)
- platelets
- vessel
- vWF protein
VWF and collagen
adhesion
shape change
activation
granule content release
secretion
platalet-platelet interaction
aggregation
secondary hemostasis
fibrin clot
turns finibrogen to fibrin
thrombin
transglutaminase
FXIII
quiescent endothelium
- barrier function mantained
- anticoagulant, antithrombotic surface
- non-adhering surface for leukocytes s
activated endothelium
- injury, infection, endothelial denudation
- activation of complement and coagulation pathways
Tissue factor: FVIIa activates
- FX
2. FIX
thrombin activates ____which then
activates FXIII which then crosslinks fibrin monomers
vit. K involved in the synthesis of
- FII
- FVII
- IX
- X
- protein C
- Protein S
vit. k is obtained
it is a fat soluble vitamin obtained through green leafy vegetables and bacterial synthesis in the gut
role of vit. K
conversion glutamic acid to gamma-carboxyglutamic acid (Gla)
inhibits vit. k epoxide reductase and thus inhibits salvage of vit. k
warfarin
stabilization of fibrin clot
FXIII, a transglutaminase activated by thrombin, stabilizes this fibrin polymer by crosslinking the fibrin strands
FXIII is a late step and not ________
reflected in screening assays
fibrinolysis
- what is it?
- physiologic
- pathologic
- release from endothelium
- tPA converts plasminogen to ______ whcih will
- breakdown of the fibrin clot
- physiologic: wound healing and maintain blood flow
- pathologic: hemorrhage
- releases from endothelium: tissue plasminogen activator (tPA)
- tPA converts plasminogen to plasmin which will cause fibrin to be degraded
Common pathway factors:
fibrinogen, prothrombin(FII), FV, FX
Intrinsic pathway factors:
common pathway and FVIII, FIX, FXI, and FXII
Extrinsic pathway factors: common pathway and FVII
common pathway and FVII
partial thromboplastin time is part of the (PTT)
intrinsic system
prothrombin time is part of the (PT)
extrinsic system
