Hematopoietic Stem Cells And Hematopoiesis

Question 1

Two fundamental properties of homeopoetic stem cells

Answer 1

1. Multi-lineage differentiation

2. Self-renewal

Question 2

Sources of hematopoietic stem cells

Answer 2

1. Autologous
2. Syngenic
3. Allogenic
4. Haploidentical

Question 3

Properties of hematopoietic stem cells

Answer 3

1. Undifferentiated
2. Relatively quiescent
3. Asymmetric division

Question 4

How are hematopoietic stem cells undifferentiated

Answer 4

Do not express mature markers

Question 5

Asymmetric division of hematopoietic stem cells

Answer 5

Generate one daughter cell that differentiated and one that self-renews

Question 6

Only the hematopoietic stem cells can self-renew

Answer 6

Yep

Question 7

Disease of aberrant proliferation

Answer 7

Cancer

Question 8

One way to protect against cancer is to _________ to a small compartment of progenitors

Answer 8

Limit self-renewal

Question 9

How long does it take to make a granulocyte from stem cells?

Answer 9

About 21 days

Question 10

Act on progenitors to control blood cell production

Answer 10

Myeloid cytokines

Question 11

Epo is a true

Answer 11

Hormone

Question 12

Myeloid growth factors act through cell surface receptors triggering

Answer 12

Dimerization and activation of cell kinases

Question 13

Blood cell development takes place

Answer 13

Within a highly specialized bone marrow micro environment ( bone or sinusoid lumen)

Question 14

Clinical use of hematopoietic growth factors:

Epo

Answer 14

• anemia of chronic kidney failure

- chemo-induced anemia

Question 15

Clinical use of hematopoietic growth factors:

Thrombopoietin

Answer 15

• ITP

- chemo-induced thrombocytopenia

Question 16

Clinical use of hematopoietic growth factors:

Granulocyte colony-stimulating factor

Answer 16

• chemo- induced neutropenia

- aplastic anemia

Question 17

Clinical use of hematopoietic growth factors:

Granuclocyte

Answer 17

• chemo-induced neutropenia

Question 18

pancytopenia

Answer 18

low blood count

Question 19

anemia

Answer 19

low RBC

Question 20

leukopenia

Answer 20

low WBC

Question 21

thrombocytopenia

Answer 21

low platelets

Question 22

progenitor cells more common than HSC?

Answer 22

yep

Question 23

morphologically distinct blood cells are produced only at the _______ stages of differentiation

Answer 23

terminal

Question 24

lifespan of a neutrophil

Answer 24

> 12 hr

Question 25

Erythropoietin and IL3 act on progenitors in the _________ lineage, and thrombopoietin and IL6 act on the ___________ lineage.

Answer 25

Erythropoietin and IL3 act on progenitors in the red cell lineage, and thrombopoietin and IL6 act on the megakaryocyte lineage.

Question 26

The aim of a hematopoietic stem cell transplant is to replace the hematopoietic system of the recipient. The only way to maintain the new hematopoietic system long-term is with cells that have long-term repopulating and self-renewal capability. Which is it?

Answer 26

Only the hematopoietic stem cell, which carries the surface marker antigen CD34, has this capability.

Question 27

is a disorder of granulopoiesis characterized by 21-day oscillations in the number of circulating neutrophils, usually due to a mutation in the gene for neutrophil elastase.

Answer 27

Cyclic neutropenia

Question 28

treatment for cyclic neutropenia

Answer 28

ngoing treatment with G-CSF does not prevent the cyclical fluctuation in the neutrophils count but does raise the baseline neutrophil count enough so that recurrent infections are prevented.