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Block 7 Week 4 > Coagulation-Fung > Flashcards

Flashcards in Coagulation-Fung Deck (196)
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1

What are the three steps of normal hemostasis?

Vasoconstriction
platelet aggregation
fibrin formation

2

What are the three steps of primary hemostasis?

1. adhesion
2. degranulation
3. aggregation

3

What is this:
with injury Von Willbrand Factor and collagen are exposed on the subendothelial basement membrane
Platelet receptor GPIb binds to Von willebrand factor

Adhesion

4

What is this:
-platelets release their alpha and dense granules
-synthesize and release TXA2

Degranulation

5

What is this:
-Platelet receptor GPIIB/IIIa and fibrinogen allows platelets to aggregate to one another

aggregation

6

Where are almost all factors except for Von willbrand factor produced?

liver

7

Where is von willebrand factor produced?

endothelial cells
megakaryocytes

8

What is another name for factor I?

fibrinogen

9

What is another name for factor II?

Prothrombin

10

What is another name for factor VIII?

antihemophilic factor

11

What is another name for factor IX?

christmas factor

12

What is another name for factor XII?

Hagemann factor

13

What is another for factor XIII?

Fibrin stabilizing factor

14

What is the common pathway for the intrinsic and extrinsic pathways of coagulation?

factor X-> Xa

15

When wil the intrinsic coag cascade happen?

with contact phase

16

When will the extrinisc coag cascade happen?

tissue injury and tissue factor

17

What is the intrinisc pathway?

XII->XIIa-> which converts IX to IXa and VIII is converted to VIIIa by IIa. VIIIa and IXa will make X which will go to Xa which will convert prothrombin (II) to thrombin (IIa) which will convert fibrinogen to fibrin. Factor XIII will then turn into factor XIIIa which wil convert fibrin into cross linked fibrin

18

What is the extrinsic pathway?

VII is converted to VIIa which converts X to Xa* which will combine with Va* (made from IIa converting V to Va*)
Va* and Xa* convert prothrombin (ii) into thrombing (iia) which converts fibrinogen to fibrin which when combined with XIIIa will create cross linked fibrin

19

What makes up the prothrombinase complex?

Va and Xa

20

What makes up the tenase complex?

VIIIa, Xa, Ca

21

What is this:
the balance between clotting and thrombosis

hemostasis

22

Hemostasis is a precisely orchestrate process involving (blank), (blank), and (Blank)

pateletes
clotting factors
endothelium

23

Where does hemostasisi occur?

at site of vascular injury and culminates in the formation of a blood clot

24

What are 2 disorders of hemostasis?

hemorrhagic disorders
thrombotic disorders

25

What is this:
characterized by excessive bleeding

Hemorrhagic disorders

26

What is this:
Characterized by clot formation

thrombotic disordes

27

Why do we get vasoconstriction in hemostasis and how?

-reduces blood flow to area, -mediated by reflex neurogenic mechanisms and augmented by local secretion of endothelin
(transient effect)

28

What is primary hemostasis?

-platelets adhere to endothelium and are activated
-this process leads to agregation and the beginning of a clot

29

What is secondary hemostasis?

-tissue factor is exposed at the site of vascular injury
-sets in motion a cascade of reactions that leads to thrombin fomration

30

(blank) release causes vasoconstriction

endothelin