Colorectal Adenocarcinoma Flashcards Preview

Conditions: GI > Colorectal Adenocarcinoma > Flashcards

Flashcards in Colorectal Adenocarcinoma Deck (28):
1

How common is colorectal adenocarcinoma?

2nd most common cause of cancer death in the UK

2

What is the aetiology of colorectal adenocarcinoma?

Genetics
- HNPCC
- FAP

Disease
- Crohn's
- UC

Lifestyle
- Smoking
- Poor diet

3

What are the symptoms of bowel cancer dependent on?

What side it is on

4

What are the symptoms of bowel cancer in general?

Abdo mass

Pain

Obstruction

Perforation

5

What are the symptoms of bowel cancer on the left?

PR bleeding and mucus

Altered bowel habit

6

What are the symptoms of bowel cancer on the right?

Weight loss

Aneamia

Abdo pain

7

What is the staging algorithm of bowel cancer?

Duke's Classification

8

What is Dukes stage 1 and survival rate?

Cancer hasn't invaded past the muscularis mucosae
- 90% survival

9

What is Dukes stage 2 and survival rate?

Cancer has invaded past the muscularis mucosae
- 65%

10

What is Dukes stage 3 and survival rate?

Cancer has invaded regional lymph nodes
- 30%

11

What is Dukes stage 4 and survival rate?

Cancer has distant mets
- <10%

12

What screening program is there for bowel cancer?

Faecal occult blood test kits sent to homes and tested

13

What investigations can be done if occult blood is detected?

Proctoscopy
Endoscopy

CT/MRI

Liver ultrasound for mets

14

What is shown on bloods in some cases?

Microcytic anaemia
- Small red blood cells

15

What antigen can be used to help with staging and treatment efficacy?

CEA
- Cryoembryonic antigen

16

What does the surgical treatment of bowel cancer depend on?

The side it's on

17

What can be done for right sided?

Right hemicolectomy

18

What can be done for left and rectal?

Left hemicolectomy

Abdominoperinal resection for rectal

19

What role can radiotherapy play?

Can be used neoadjuvantly
- May increase survival rate but also increase chance of complication

20

What role can chemotherapy play?

Increase survival

Palliation

21

What Dukes' stages is chemotherapy used in?

B (sometimes)

C (good evidence)

22

What role do NSAIDs and aspirin play in colorectal cancer?

Evidence that they might be preventative

23

What other surgeries may need to be done in the management of colectomys?

Colostomies put in

24

What are the 3 types of polyp?

Inflammatory

Hamartomatous

Neoplastic

25

What causes inflammatory polyps?

IBD

26

What causes hamartomatous polyps?

Peutz jeghers syndrome

27

What causes neoplastic polyps?

Adenomas

28

What is peutz jeghers disease?

Autosomal dominant disorder causing hamartomatous growths in the bowel

Increases risk of bowel cancer by 20x