Complement

Question 3

MBL function

Answer 3

Binds to mannose

Question 4

MBL pathway

Answer 4

Lectin

Question 5

MBL associated diseases

Answer 5

Mostly asymptomatic
Bacterial infections
Some autoimmunity

Question 6

MASP-1 Function

Answer 6

Unknown

Question 7

MASP-1 pathway

Answer 7

Lectin

Question 8

MASP-1 associated diseases

Answer 8

3MC syndrome

Question 9

MASP-2 function

Answer 9

Cleaves C4 and C2

Question 10

MASP-2 pathway

Answer 10

Lectin

Question 11

MASP-2 associated diseases

Answer 11

Mostly asymptomatic
Respiratory infections

Question 12

Factor B function

Answer 12

Binds to C3b to form C3 convertase

Question 13

Factor B pathway

Answer 13

Alternative

Question 14

Factor B associated diseases

Answer 14

Neisseria and pneumococcal infections
aHUS with gain of factor

Question 15

Factor D function

Answer 15

Cleaves factor B

Question 16

Factor D pathway

Answer 16

Alternative

Question 17

Factor D associated diseases

Answer 17

Bacterial infection

Question 18

Properdin function

Answer 18

Stabilizes C3bBbC3 convertase

Question 19

Properdin pathways

Answer 19

Alternative

Question 20

Properdin associated diseases

Answer 20

Severe recurrent infections

Question 21

C3 function

Answer 21

Key intermediate in all pathways

Question 22

C3 pathways

Answer 22

Terminal

Question 23

C3 associated diseases

Answer 23

Severe recurrent infections
aHUS, C3G, and AMD with gain of function

Question 24

C5 function

Answer 24

Initiates MAC

Question 25

C6 function

Answer 25

Binds to C5b in MAC

Question 26

C7 function

Answer 26

Binds to C5bC6 in MAC

Question 27

C8 function

Answer 27

Starts pore formation

Question 28

C5, C6, C7, C8 pathway

Answer 28

Terminal

Question 29

C5, C6, C7, C8 associated disease

Answer 29

Neisseria infection

Question 30

C9 function

Answer 30

Polymerizes to cause cell lysis

Question 31

C9 pathways

Answer 31

Terminal

Question 32

C1q Function

Answer 32

Binds to Fc region of IgM and IgG Synaptic pruning

Question 33

C1r function

Answer 33

Activates C1s

Question 34

C1s function

Answer 34

Cleaves C4 and C2

Question 35

C1 pathway

Answer 35

Classical

Question 36

C1 associated diseases

Answer 36

SLE Recurrent infections

Question 37

C4 function

Answer 37

Part of C3 convertase

Question 38

C4 pathway

Answer 38

Classical

Question 39

C4 associated diseases

Answer 39

Often asymptomatic Rheumatoid arthritis SLE Infection

Question 40

C2 function

Answer 40

Binds to C4b to form C3 convertase

Question 41

C2 pathway

Answer 41

Classical

Question 42

C2 associated diseases

Answer 42

SLE recurrent infections May be asymptomatic

Question 43

The classical pathways is activated primarily by

Answer 43

Antigen-antibody complexes

Question 44

Name a characteristic of complement components

Answer 44

Normally present in serum

Question 45

Recognition unit

Answer 45

Consists of C1qrs The subunits require calcium for binding Binding occurs at the Fc region of antibody molecules

Question 46

Synonyms for C3 convertase

Answer 46

C4bC2a C3bBb

Question 47

Mannose binding protein in the lectin pathway is most similar to what classical pathway component?

Answer 47

C1q

Question 48

Role of Properdin in the alternative pathway

Answer 48

Stabilization of C3 convertase

Question 49

MAC

Answer 49

C9 polymerizes to form the transmembrane channel

Question 50

Functions of complement system

Answer 50

Lysis of foreign cells Increase in vascular permeability Migration of neutrophils to the tissues

Question 51

Diseases associated with complement deficiencies or improper control

Answer 51

AMD PNH aHUS C3 glomerulopathy

Question 52

Amplification loop

Answer 52

Improper control can lead to disease It can amplify activation that is initiated by the classical pathway C3b is the product that is increased

Question 53

Factor H acts by competing with ___ for the same binding site

Answer 53

Factor B

Question 54

If a specimen for complement testing was left on a laboratory bench overnight, and not properly frozen, what would happen?

Answer 54

A CH50 level would be falsely low

Question 55

A lack of C1-INH has been associated with

Answer 55

Hereditary angioedema

Question 56

Cofactors for Factor I

Answer 56

Membrane cofactor protein C4-binding protein Factor H

Question 57

Anaphylatoxin

Answer 57

Increases permeability of blood vessels

Question 58

A decreased in CH50 level and a normal AH50 level indicates

Answer 58

Decrease in components of the classical pathway

Question 59

The CH50 test measures

Answer 59

Patient serum required to lyse 50% of sensitized sheep RBCs

Question 60

HUS

Answer 60

Common cause of renal failure in children

Question 61

What would be expected of a patient on a complement C5 inhibitor

Answer 61

Low CH50 and AH50

Question 62

The role of CR2 on cell membranes

Answer 62

Acts as co-receptor on B cells for antigen