Complex Molecules Flashcards

(77 cards)

1
Q

Glycoproteins

A

Mucoprotein

Protein> Carbohydrates

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2
Q

Glycosaminoglycans

A

Mucopolysaccharides

Carbohydrates> proteins

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3
Q

Glycerophospholipids

A

Phosphoglycerides

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4
Q

Proteins to which oligosaccharides are attached

A

Glycoproteins

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5
Q
Glycoproteins
The oligosaccharides are usually attached to \_\_\_\_\_ (O-linked in golgi bodies)
Or \_\_\_\_\_\_ (N-linked, synthesized in endoplasmic reticulum)
A

Serine

Asparagimed

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6
Q

Glycoproteins

Lubricant and protective agent in the gastrointestinal and urogenital tracts

A

Mucin

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7
Q

Glycoproteins

Examples of transport molecules

A

Transferrin

Cerruloplasmin

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8
Q

Glycoproteins

Hormones

A

HGC

TSH

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9
Q

Glycoproteins

Immunoligic fxn

A

Immunoglobulins

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10
Q

Glycoproteins

Dse associated

A

I-cell disease

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11
Q

Unbranched polysaccharides consisting if repeating disaccharide units, alternating ACIDIC SUGAR-AMINO SUGAR

A

GAGs

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12
Q

GAGs

Acidic sugars

A

Glucuronic acid

Iduronic acid

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13
Q

GAGs

Amino sugars

A

Glucosamine

Galactosamine

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14
Q

Except for __________, the GAGs are normally linked to a protein core, and the emtire structure is called _____

A

Hyaluronic acid

Proteoglycan

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15
Q

GAGs

Cell migration and wound repair

A

Hyaluronic acid

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16
Q

GAGs
Principal component of cartilage
Found in sites of calcification
Most abundant GAG

A

Chondroitin sulfate

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17
Q

GAGs

Anticoagulant

A

Heparin

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18
Q

GAGs

Receptors for cell griwth and cell-cell communication, maintains charge selectivenedd of renal glomerulus

A

Heparan sulfate

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19
Q

GAGs

Main GAG in skin

A

Dermatab sulfate

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20
Q

GAGs diseases

A

HHM (mucopolysaccharidoses)

Hunter syndrome
Hurler syndrome
Morquio syndrome

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21
Q

Glycerol + 2FA + phosphate group + alcohol

A

Glycerophospholipids

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22
Q

Phospholipid in which an alcohol is attached by a phosphodiester bridge to diacylglycerol

A

Glycerophospholipids

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23
Q

Glycerophospholipids

Aka lecithin

A

Phosphatidylcholine

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24
Q

Glycerophospholipids
Most abundant
Cell membrane outer leaflet
Storage of cholinr component of acetylcholine

A

Phosphatidylcholine

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25
Glycerophospholipids | Aka cephalin
Phosphatidylethanolamine
26
Glycerophospholipids | Cell membrane inner leaflet
Phosphatidylethanolamine
27
Glycerophospholipids Cell membrane inner leaflet Plays a role in apoptosis
Phosphatidylserine
28
Glycerophospholipids | Reservoir of arachidonic acid in cell membrane, source of inosito, triphosphate + DAG, which are second messengers
Phosphatidylinositol
29
Glycerophospholipids Dipalmitoyllecithin Lung surfactant
Dipalmitoylphosphatidylcholine
30
Glycerophospholipids Antigenic Cross-reacts with antibodies to syphilis
Cardiolipin
31
Sphingosine + FA + phosohate + choline
Sphingophospholipid
32
The only significat sphingophospholipid Constituent of myelin sheath Insulates axons of nerve fiberd Increases nerve conductioj
Sphingophospholipid
33
Glycolipids
Glycosphingolipids | Lipid>Carbohydrates
34
Sphingosine+FA+x
Glycosphingolipids
35
Derivatives of ceramide, in which a long chain FA is attached to ansphingosine backbone
Glycosphingolipids
36
Name of glycolipid depending on X | H atom
Ceramide
37
Name of glycolipid depending on X | Glucose or galactose
Cerebroside
38
Name of glycolipid depending on X | Di, tri, or tetrasaccharide
Globoside
39
Name of glycolipid depending on X | N-acetyl muramic acid
Ganglioside
40
Name of glycolipid depending on X | Sulfated glucose
Sulfatide
41
Essential component and contribute to the assymetry of the cell membrane (outer leaflet) Play a role in crll adhesion and recignition, growth, and develop,ent Important on neural tissue
Glycolipids
42
Sphingolipidoses
Tasy sachs Nieman. Pick dse Gaucher dse
43
Eiscosanoids (3)
PG TX Leukotrienes
44
20 C FA from which eicosanoids are derived
Arachidonic acid
45
Enzyme that cleaves arachidonic acid | Yields eicosanoids
Phospholipase A2
46
Enzyme that cleaves arachidonic acid | Yields prstaglandins and thromboxanes
Cyclooxygenase
47
Enzyme that cleaves arachidonic acid | Yields leukotrienes
Lipoxygenase
48
Eicosanoid Mediators of inlammation and pain Protect gastric mucosa
Prostaglandins
49
Eicosanoid Promotes thrombosis (platelet adhesion, aggregation) Vasocinstriction Produced by platelets
Thromboxane
50
Eicosanoid Inhibits thrombosis Stimulates vasodilatation Produced by endothelial cells
Prostacyclin
51
Eicosanoid Keeps ductus arteriosus open Used for erectile dysfunction
PGE1 (alprostadil)
52
Eicosanoid Vasodilation Relaxation of smooth muscles Induces labor
Pge2
53
Eicosanoid Vasoconstriction Smooth muscle contraction Uterine contractions
PGF2a
54
Eicosanoid Slow acting substances Anaohylaxis Bronchial constriction
Leukotrienes
55
Lipid accumulation disorder | Def a L iduronidase
Hurler syndrome | MPS I
56
Lipid accumulation disorder | Def iduronate sulfatase
Hunter syndrome | MPS II
57
Lipid accumulation disorder | Def Heparan sulfate N sulfatase
Sanfilippo type A
58
Lipid accumulation disorder | Def a N acetyl glucosaminidase
Sanfilippo type B
59
Lipid accumulation disorder | Def a glucosaminidase Nacetyltransferase
Sanfilippo type C
60
Lipid accumulation disorder | Def N acetylglucosamine 6 sulfatase
Sanfilippo type D
61
Lipid accumulation disorder | MPS III
Sanfilippo
62
Lipid accumulation disorder | Def galactose6sulfatase
Morquio type A
63
Lipid accumulation disorder | Beta galactosidase
Morquio type B
64
Lipid accumulation disorder | MPS IV
Morquio
65
Lipid accumulation disorder | Beta glucuronidase
Sly syndrome
66
Lipid accumulation disorder | Def beta glucuronidase
Sly syndrome
67
Lipid accumulation disorder | MPS VII
Sly syndrome
68
Lipid accumulation disorder GAGs affected: Dermatan and heparan sulfate
Hurler syndrome and hunter syndrome
69
Lipid accumulation disorder Lipid accumulation disorder GAGs affected: Heparan sulfate
Sanfilippo
70
Lipid accumulation disorder GAGs affected: Keratan and chroitin sulfate Keratan sulfate
Morquio A and B
71
Lipid accumulation disorder GAGs affected: Dermatan s Heparan s Chrindroitin
Sly syndrome
72
Lipid accumulation disorder ``` Mental retardation Coarse facial features Hepatosplenomegaly Corneal clouding Death in childhood ```
Hurler
73
Lipid accumulation disorder Mental retardation Similar to hurler but no corneal clouding X linked
Hunter
74
Lipid accumulation disorder Mental retardation Hyperactivity
Sanfilippo
75
Lipid accumulation disorder ``` Skeletal dysplasia Short stature Odontoidnhypoplasia Corneal clouding No CNS involvement ```
Morquio
76
Lipid accumulation disorder | All are autosomal except
Hunter syndrome (x linked)
77
Lipid accumulation disorder | All have mental retardation except
Morquio