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Flashcards in Components of Blood Deck (19):
1

Components of Blood

- 55% of blood is plasma
- 45% of blood is blood cells

2

Define Plasma

- fluid in blood

Contains:
- 90% water
- Proteins
- Glucose
- Vitamins
- Minerals
- Dissolved gases
- Waste products of cellular metabolism

3

Blood cells contain:

- RBC
- WBC
- Platelets

4

Red blood cells (RBC)

- biconcave discs around 7um in diameter
- Shape provides greater surface area for gas exchange
- Live about 120 days (4 months)
- 5 million produced every min
- Do not have nucleus, carries more hemoglobin
- Produced in bone marrow
- Iron needed to make RBC
- Erythrocytes

Ave male = 5.5 million RBC/ml
Ave female = 4.5 million RBC/ml

5

Regulation of Erythrocytes (RBC)

- WBC monitor age and amount of RBC
- WBC remove debris from the circulatory system
- Breakdown of RBC = released hemoglobin
- Iron is recovered and stored in liver and bone marrow
- Heme transforms to bile pigments

6

Anemia

- Reduction of blood oxygen from low lvls of hemoglobin or poor RBC production
- Deficiency in RBC/hemoglobin leads to decreased oxygen delivery to tissues
- Characterized by low energy lvls

Due to:
- Hemorrhage
- Iron Deficiency

7

Sickle Cell Anemia

- Hereditary blood disorder
- Abnormality in hemoglobin molecule in RBC
- cells assume an abnormal, rigid, sickle like shape
- Creates chronic health problems (infections, severe pain, stroke, increased risk of death)
- Gets stuck -> blood clots

8

WBC

- Leukocytes
- Less than RBC
- Has a nucleus, its shape and size is used to identify different types of WBC
- Function: destroy invading microbes by phagocytosis
- When microbe is engulfed, WBC releases an enzyme that digest the microbe and the WBC itself (cell suicide=apoptosis)

9

Types of WBC

- Neutrophils
- Eosinophils
- Monocytes
- Macrophages
- Basophils

10

Neutrophils

Eat and kill bacteria; role in inflammation

11

Eosinophils

Kill parasites; role in allergies

12

Monocytes

Develop in macrophages

13

Macrophages

Phagocytoze microbes
role in inflammation
- Show antigens to T cells

14

Basophils

Secrete anti-clotting factors

15

Thrombocytes = platelets

- Do not have a nucleus
- Important role in blood clotting
- When blood vessel is damaged, cells of the vessel wall release a substance that makes them sticky, then platelets start to stick to injury site
- When platelets build up, they form a plug to stop the bleeding
- Change shape from round to spiny and release substances that trap more platelets and clot blood

16

Blood Clotting

- Platelets release a protein called Thromboplastin
- Prothrombin using Thromboplastin creates Thrombin
- Thrombin is used to convert Fibrinogen to Fibrin

17

Fibrin

Wraps around the damaged area, trapping RBC and more platelets to form a clot and stop bleeding

18

Blood Clot

- Aka Thrombus
- Bloods blood vessel -> inhibiting blood from passing through the area
- Local tissues not supplied with O2 and nutrients
- Can cause stroke
- Coronary thrombosis -> clot in coronary artery

19

Embolus

When blood clot dislodges and travels to a vital organ

Three main types:
- Cerebral embolism
- Coronary embolism
- Pulmonary embolism