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Flashcards in Immune Response Deck (22):
1

1st line of defense (generalization)

- non-specific
- Physical
- Surface protection that keep microbes from getting into the body
1. Skin
2. Lysozymes
3. HCl
4. Cilia

2

2nd line of defense (generalization)

- Non-specific
- Chemicals that comes immediately into play if things makes it past the 1st line
- Include macrophages, neutrophils, and monocytes
- Cell-mediated immunity

3

3rd line of defense (generalization)

- Specific
- Antibodies that are developed uniquely for each microbe through action of specialized WBC’s
- Antibody-Mediated Immunity
- Lyphocytes : B cells and T cells

4

HCl

- Stomach Acid
- Destroy invading microbes carried in food

5

Skin

- Protective barrier
- Acidic enough to inhibit growth of microbes

6

Lysozymes

- Enzymes produced in tears, salvia, mucus, and perspiration
- Destroy cell walls of bacteria

7

Cilia

- Found in respiratory tract
- Trap microbes and foreign debris
- Cough/sneeze to expel

8

Role of monocytes in 2nd line of defense

- Move into tissues and become macrophages and phagocytose foreign invaders
- Extend protrusions(pseudopods), that attach to surface of invading microbe and engulf and destroy it bu enzymes

9

Role of neutrophils in 2nd line defense

- Move into infected tissues by a process called chemotaxis

10

Define Chemotaxis

Chemical signals given off by calls that have been damaged by microbes and eat microbe and damaged WBC

11

Pus

Remaining fragments of protein, dead WBC and digested invaders

12

Inflammatory Response

- Initiated by tissue damage due to physical injury
- A non-specific immune system response resulting in swelling, redness, heat and pain

13

Fever

- System wide defense to more severe damage or infections
- When neutrophils or macrophages digest invaders, they release chemicals which go to your brain and increase your temperature, which kills invaders
- Makes it difficult for harmful bacteria to survive

14

B cells

- Mature in bone marrow
- B cells
- Memory B cells

15

T cells

- Mature in thymus gland
- Helper T cells
- Killer T cells
- Suppressor T cells

16

Helper T cells

Identify foreign invaders and sends information to B cells/plasma cells

17

B cells and plasma cells

Produce antibodies that are specifically for the antigen

18

Killer T cells

Puncture cell membranes of infected cells

19

Suppressor T cells

Turn off immune system

20

Memory B cells

Retain information about shape of antigen for future infections

21

Antibodies

- Y shaped proteins that recognize foreign substances and act to neutralize or destroy them
- Specific to invader

22

Antigen-antibody complex

Antibody binds to antigen to create complex which gets destroyed by macrophages to prevent them from entering cells