Connective Tissue Disease 2 Flashcards Preview

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Flashcards in Connective Tissue Disease 2 Deck (20)
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1
Q

name some rheumatological autoimmune diseases

A
SLE
Sjogren`s syndrome
Systemic sclerosis
Mixed connective tissue disease
Inflammatory myositis(Polymyositis/Dermatomyositis)
Anti-phospholipid antibody syndrome
2
Q

name the first phase in Raynauds

A

phase 1 - Ischemia

3
Q

name the second phase in Raynauds

A

phase 2 - cyanosis

4
Q

name the third phase in Raynauds

A

phase 3 - rubor

5
Q

who does Raynauds affect?

A

teenagers - benign

elderly - secondary to underlying autoimmune disease

6
Q

what is the treatment in Raynauds?

A

keep warm
vasodilators - Calcium channel blockers
PDE5 inhibitors - slinenafil

7
Q

name the 2 types of systemic sclerosis

A

varieties-Diffuse cutaneous systemic sclerosis (dsCC)and limited cutaneous systemic sclerosis(lsCC)

8
Q

what did systemic sclerosis use to be called?

A

scleroderma (skin thickening)

9
Q

name the skin involvement in limited cutaneous SSc

A

only below elbows and knees plus face

10
Q

what is the acronym in systemic sclerosis?

A

CREST

11
Q

name the manifestations in systemic sclerosis

A
sclerodactyly
telangiectasia
pulmonary fibrosis
pulmonary hypertension
scleroderma renal crisis
12
Q

what is the antibody that is important in systemic sclerosis?

A

anticentromere

13
Q

name the management in systemic sclerosis

A

Yearly ECHO and PFTs.
Treat Raynaud`s and digital ulcers.
Treat reflux with PPi +/_ranitidine+/_Gaviscon .
Pulmonary fibrosis- immunosuppression.
Rapidly progressive skin involvement-immunosuppression.
Pulmonary hypertension-Prostacyclin analogues, endothelin receptor antagonists, PDE5 inhibitors.
Tight control of blood pressure-ACE INHIBITORS.

14
Q

what is Sjogrens syndrome characterised by?

A

lymphocytic infiltration of exocrine glands

15
Q

what is typical of sjogrens syndrome?

A
Blepharitis.
Salivary gland inflammation.
Tooth decay.
Lymphoma.
Dry cough.
Multisystem involvement
16
Q

what is the key word in sjogrens syndrome?

A

dryness

17
Q

name the 2 antibodies important in sjogrens

A

Anti Ro and Anti La

18
Q

how do you diagnose sjogrens?

A

antibodies

salivary gland US and biopsy

19
Q

what is the treatment in sjogre’s syndrome?

A

Therapeutic spectrum.

Artificial tears and salivary supplements,vaginal lubricants.

Good dental hygiene-strong fluoride toothpaste-e.g.Duraphat.

Hydroxychloroquine for fatigue and arthralgia.

Immunosuppression for major organ involvement.

20
Q

how do you diagnose antiphospholipid antibody syndrome?

A

presence of antiphospholipid antibodies on 2 occasions 12 weeks apart