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Module 7 > Cortical Development > Flashcards

Cortical Development Flashcards

(38 cards)

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1
Q

Stages of Brain Development

A
  • 0-4 weeks: Neurolation
  • 4-8 weeks: Neuronal Proliferation
  • 12-Birth: Neural Migration
  • 16/18 weeks – late childhood: Apotosis
  • 18 weeks – Late childhood: Synaptogenesis
  • 30 weeks – Adulthood: Myelination
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2
Q

Neuronal Proliferation

A

Neurons destined for the neocortex are produced in the proliferative zone near the cerebral ventricle (ventricular zone)

(proliferation means cells greatly increase in #)
organizer controls pattern of proliferation via chemical signals in neural tube

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3
Q

Neurolation

A

Folding & fusion of the ectoderm to create the neural tube
Neural tube becomes the CNS

Happens week 0-4;

Week 5: ecotoderm differentiated into different brain structures

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4
Q

Neural Migration

A

Neurons migrate along radial glial cells to the relevant layer of the cortex

phase 3 of prenatal development

cells need to migrate from ventricular zone and aggregate in this process

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5
Q

Brain volume growth

A

Total: Peak = 10 (females) & 14 (Males)

Grey: Peak = 10 (males) & 8 (females)

WM: steep increase in first year; Then less rapid growth up to young adulthood

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6
Q

Grey Matter in adolesence

A

So despite global changes in GM – we can see that it the thickness that is showing the most marked reduction

Change in grey matter volume refers to a change in:
Thickness
Surface area

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7
Q

Sulcation

A

Process of brain growth in the 2nd – 3rd trimester

Abnormality = Lissencephaly (smooth brain)

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8
Q

Abnormality of sulcation

A

Lissencephaly (smooth brain)

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9
Q

Gyrification

A

development of the surface folds

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10
Q

Sulcation development

A

13-17 gestational weeks - appearance of the first sulcus
18-19 gestational weeks - development of the periinsular sulci
20-22 gestational weeks - central sulci and opercularization of the insula
24-26 gestational weeks - covering of the posterior insula
27-28 gestational weeks - closure of the lateral sulcus (Sylvian fissure or lateral fissure)

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11
Q

3 types of sulci

A

Primary
Consistently located
Easily recognisable
Central and Superior Frontal

2) Secondary
Branches of the Primary Sulci

3) Tertiary
Branches of the secondary Sulci
Individual differences
8/9month of pregnancy and into first year of life

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12
Q

Theories of Gyrification

A
  • Skull preventing the brain growing
  • Axonal Tension Theory
  • Differential Radial Growth – Richman 1975
  • Differential Tangential Growth – Ronan 2014
  • Constrained cortical expansion - Tallinen 2014, 2016
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13
Q

Axonal Tension Theory

A

Axons connecting two areas are pulling on cortex and this causes them to fold. BUT: Axonal tension does exist but it quite weak; there are more gyri than sulci

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14
Q

Constrained Cortical Expansion

A

Grey matter is expanding rapidly
White matter isn’t
Based on this theory:

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15
Q

Polymicrogyria based on Constrained Cortical Expansion Theory

A

Poly microgryia = thin cortex but large surface area so it folds more

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16
Q

Lissencephaly based on Constrained Cortical Expansion Theory

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A

Lisencephaly = thick cortex but low surface area so it folds less

17
Q

2 ways neurons migrate along radial glial cells

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A

2 ways cells move:
radial migration: move out in a straight line
tangential migration: cells travel in right angles

18
Q

Radial Unit Hypothesis process…

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A 
1. Ventricular zone = Generate Neurons
Intermediate Progenitor (IP) divide to forms pairs of neurons
  1. Neurons Transverse Intermediate zone and Subplate Zones along RG cells
  2. Pass through deep layers and settle between Cortical Plate and Marginal Zone
19
Q

Symmetrical Radial Division

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A

Laterally – side way and therefore affects surface area

20
Q

Asymmetrical Radial Division

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A

Linear increase in radial coloumns results in an increase in cortical thickness

21
Q

What determines position of neurons in neuronal migration?

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A

Position of the neurons is determined by information in the VZ + a protomap in the SP and CP & is preserved by transient radial glial scaffolding

22
Q

What impacts cortical thickness?

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A

The number of IP and RG cells = cortical thickness

23
Q

Human Vs. Rodent Brain

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A

Outer sub-ventricular zone = larger

the division of the RG cells fromm sub-ventricular RG cells - which allows for ‘extra coloumns’ and a much larger cortex

24
Q

oRG

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A

oRG = non-epithelial radial-glial like cells – able to self renew and produce neurons similar to classic RG cells
oRG and classic RG divide asymmetrically to produce IP cells
IP cells divide once or twice to produce immature neurons

oRG cells and IP cells are known as ‘transit amplifying neurons’ as they amplify the number on neurons being migrated
THEREFORE contribute to the larger cortex in humans

25
Founder cells
during cortical development radial founder cells go through stages of symetrical cortical division to generate founder cells. Once the set number of founder cells is reached (different between species) the cells begin to divide assymetrically: forming one ventricular zone RG (vzRG) cell and one immature neuron – the immature neuron migrates up the RG fibre.
26
Cortical layer formoation
After ascending the RG fibres the immature neurons form somewhere between the CP and Marginal Zone to form a cortical layer IMP not only is the layer position important but also the coloumnar position Despite being in different layers research found that neurons in the same COLOUMN respond to the same orientation of a bar of light
27
Congenital Anopthalmia & Cortical development
Removing monkey’s eyes at 60 days old = reduced LG nucleus (1/2) + folds of occipital lobe are completely different WHY? Hypotheses: Thalamic input impact the surface area of V1: no eyes, reduced thalamic input, reduced V1 size The neurons of this area (Area 17) formed a Hybrid Cortex They have characteristics of area 17 but received input from Area 18
28
Class 1 Brain Malformations
Class 1 – number of radial units reduced Happens in first 6 weeks Reduced surface area as there are reduced number of radial colomnar units for neurons to migrate along e.g. Microcephaly
29
Class 2 Brain Malformations
Class 2 – Number of neurons in each radial unit is reduced After 6 weeks Occurs due to interference with cell proliferation or migration Reduced thickness as reduced neurons to migrate
30
Class 3 Brain Malformations
Class 3 – Malformations of cortical organisation within the 6 layers
31
Microcephaly
Class 1 Reduced surface area – reduction in number of radial unit coloumns Non-genetic Causes Genetic Causes Zika Virus – potential link; however not solely microcephaly
32
Nongenetic causes of Microcephaly
Causes: Nongenetic -  congenital infection with toxoplasma, CMV -  Zika?? -  maternal alcohol consumption during pregnancy Genetic -  Autosomal Recessive Primary Microcephaly  Rubenstein Taybi syndrome
33
Lissencephaly
Smooth Brain Class 2 BUT Recent Research: affects a number of stages of Cortical Development Therefore may also be contributed to by Class 1 malformations: an early occuring event that affects the number of coloumns - they don’t even get to the point of not being able to migrate 2 Types: Isolated Lissencephaly Sequence (ILS) Miller-Dieker Syndrome
34
Isolated Lissencephaly Sequence (ILS)
Type of Lissencephaly -  Severe intellectual disability -  Microcephaly -  Developmental delay -  Recurrent seizures -  Genes: PAFAH1B1, DCX, or TUBA1A
35
Miller-Dieker Syndrome
Type of Lissencephaly -  Severe intellectual disability -  Developmental delay -  Seizures -  Spasticity -  Hypotonia -  Feeding difficulties -  Distinctive facial features
36
Polymicrogyria
Signs and symptoms depends on how many brain regions are affected Its a disruption of the organisation rather than production or migration of the neurons 3 types: Unilateral Focal Polymicrogyria Bilateral Polymicrogyria Bilateral Generalised Polymicrogyria
37
Late maturation of Sylvian fissure
late maturation of Sylvian fissure is an indication of atypical brain development
38
Schizophrenia | Disorder of neuronal development
Regions where there are functional differences show a different growth trajectory Abnormal non-linear growth processes in prefrontal and temporal areas that have previously been implicated in schizophrenia, distinguishing fbetween cortical areas with age-constant deficits in cortical thickness and areas whose maturational trajectories are altered in schizophrenia

Module 7 (13 decks)

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