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Flashcards in CPC Neoplasia Deck (11):
1

most common cause of female cancer mortality worldwide

cervical cancer

2

what does cervical disease start as

benign noninvasive or squamous intraepithelial lesion

10-15% progress to moderate or severe dysplasia

3

mechanism of high risk HPV

protein E6 interacts with p53 in host cell-->promotes degradation via ubiquitin dependent pathway

protein E7 complexes with Rb-->inactivating it

4

Rb and p53 are

tumor suppressors

5

procedures that target the infected area..

do NOT get rid of HPV

6

procedures for HPV

leep- cuts of infected site
laser- burns off infected site
cryosurgery- freezes off infected site
general surgery- hysterectomy, vulvectomy
natural products- stress, immune system boosters

7

cervical cancer screening guidelines

approx 3 years after onset of vaginal intercourse, but no later than age 21

8

ASCUS

atypical cells of unclear significance

repeat Pap vs. test for HPV DNA

9

LSIL

low grade squamous intra-epithelial lesion

colposcopy with biopsy

10

HSIL

high grade squamous intra-epithelial lesion

colposcopy with biopsy and treat

11

CIN 1

mild dysplasia--usually spontaneously regresses