CPPS303 XIAO Lecture 1 Overview - Lipids and Lipoproteins March_10_2025 (1) (1) Flashcards
What territory are we acknowledging in the gathering?
Treaty 6 Territory and the Homeland of the Métis
Who is the instructor for CPPS 303?
Changting Xiao, PhD
What is the main textbook for the course?
Medical Physiology, Boron & Boulpaep, 3rd edition
What are the key topics covered in the lectures?
- Lipid metabolism
- Pleiotropic roles of gut hormones
- Neural circuits for nutrient and energy homeostasis
- Metabolic-related diseases
What is the first lecture about?
Overview of lipids and lipoproteins
What is a key learning objective regarding lipids?
Describe the types and characteristics of lipids
What is a key learning objective regarding lipoproteins?
Describe the types, characteristics and functions of lipoproteins
What is the main function of lipoprotein lipase?
Regulates lipoprotein metabolism
What are the main types of lipids mentioned?
- Triacylglycerol (triglyceride)
- Cholesterol
- Cholesteryl ester (CE)
- Phospholipids
What are lipoproteins made of?
- Phospholipid outer layer
- Cholesterol
- Proteins
- Neutral lipid core (Triglycerides, Cholesteryl ester)
What are the major classes of lipoproteins?
- Chylomicrons
- VLDL
- IDL
- LDL
- HDL
What is the density range for chylomicrons?
<0.95 g/cm3
What is the diameter range for LDL?
18–25 nm
What percentage of protein is found on the surface of HDL?
40–55%
Which apolipoproteins are associated with chylomicrons?
- A-I
- A-II
- B-48
- C-I
- C-II
- C-III
- E
What is the origin of VLDL?
Produced in the liver
What is the process of lipoprotein metabolism?
Lipolysis and conversion reduce size and exchange apo proteins
What is the key enzyme for the conversion of VLDL to IDL?
Lipoprotein lipase (LPL)
What factors can increase triglyceride-rich lipoproteins?
- Increased production
- Decreased clearance
What is a consequence of imbalance in lipoprotein secretion and clearance?
Dyslipidemia leading to atherosclerosis and CVD
What is the primary circulating pool in lipoprotein metabolism?
Production - Clearance
What are the preferred substrates for endothelial lipase?
Phospholipids
True or False: HDL has the highest density among lipoproteins.
True
Fill in the blank: The major classes of lipoproteins include _______.
[Chylomicrons, VLDL, IDL, LDL, HDL]
