Flashcards in crohns vs uc Deck (13):
Location: Crohn's vs UC
Crohn's = skip lesion w/ rectal sparing. Terminal ileum or colon; UC = continuous colonic lesions w/ rectal involvement
Gross - crohn's
transmural. Cobblestone mucosa. Creeping fat. Fissures, fistulas.
Gross - UC
Mcuosal and submcuosal inflammtion. Pseudopolyps. Loss of haustra (lead pipe on imaging)
Histo - Crohn's
Histo - UC
Crypt abcesses and ulcers. NO granulomas.
Complications of crohn's
strictures, fistulas, perianal disease, coloretal cancer
Complication of UC
Primary sclerosing cholangitis. Toxic megacolin. Colorectal cancer.
Clinical manifestation - Crohn's
secretory diarrhea. Migratory polyarthritis, erythema nodosum, ankylosing spondylitis, uveitis, oxalate nephrolithiasis
Clinical manifestations - UC
bloody diarrhea. Pyoderma gangrenosum. PSC, ankylosing spondylitis, uveitis.
Therapy for crohn's
corticosteroids, azathioprine, MTX, infliximab, adalimumab
Therapy for UC
ASA preparations (sulfasalazine), 6MP, Infliximab, colectomy.
Why do you get oxalate stones in Crohn's?
decreased fat absorption. Low fat absorption = low serum Ca = increased oxalate in urine bec/ Ca binds oxalate in blood