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Flashcards in crohns vs uc Deck (13):
1

Location: Crohn's vs UC

Crohn's = skip lesion w/ rectal sparing. Terminal ileum or colon; UC = continuous colonic lesions w/ rectal involvement

2

Gross - crohn's

transmural. Cobblestone mucosa. Creeping fat. Fissures, fistulas.

3

Gross - UC

Mcuosal and submcuosal inflammtion. Pseudopolyps. Loss of haustra (lead pipe on imaging)

4

Histo - Crohn's

noncaseating granulomas.

5

Histo - UC

Crypt abcesses and ulcers. NO granulomas.

6

Complications of crohn's

strictures, fistulas, perianal disease, coloretal cancer

7

Complication of UC

Primary sclerosing cholangitis. Toxic megacolin. Colorectal cancer.

8

Clinical manifestation - Crohn's

secretory diarrhea. Migratory polyarthritis, erythema nodosum, ankylosing spondylitis, uveitis, oxalate nephrolithiasis

9

Clinical manifestations - UC

bloody diarrhea. Pyoderma gangrenosum. PSC, ankylosing spondylitis, uveitis.

10

Therapy for crohn's

corticosteroids, azathioprine, MTX, infliximab, adalimumab

11

Therapy for UC

ASA preparations (sulfasalazine), 6MP, Infliximab, colectomy.

12

Why do you get oxalate stones in Crohn's?

decreased fat absorption. Low fat absorption = low serum Ca = increased oxalate in urine bec/ Ca binds oxalate in blood

13

What is toxic megacolin?

cessation of neuroactivity in intestinal wall --> distension of abdomen. Tympanic percussion. Tx: IV fluids.