P450 interactions Flashcards Preview

Step 1 > P450 interactions > Flashcards

Flashcards in P450 interactions Deck (20):
1

Acute alcohol abuse

inhibitor

2

amiodarone

inhibitor (k-channel blocker)

3

barbiturates

inducer (anxiety, seizures, insomnia, anethesia)

4

Carbamazepine

inducer (anti-convulsant, mood stabilizer)

5

Chronic alcohol use

inducer

6

Cimetidine

inhibitor (H2 antagonist)

7

Ciprofloxacin

inhibitor (fluoroquinolone - DNA gyrase inhibitor)

8

Gemfibrozil

inhibitor (fibrate, lowers triglycerides)

9

Grapefruit juice

inhibitor

10

Griseofulvin

inducer (superficial fungal infection - inhbits microtubule formation)

11

Isoniazid

inhibitior (decreases synthesis of mycolic acids

12

Ketoconazole (azole antifungals)

inhibitor (azole antifungal)

13

Macrolides (like erythromycin)

inhibitor (blcoks translocation of ribosomes)

14

modafinil

induce (daytime stimulant for narcolepsy)r

15

Phenytoin

inducer (anticonvulsant, Class IB antiarrhythmic)

16

Quinidine

inhibitior (antimalarial, Class IA antiarrhythmic)

17

Rifampin

inducer (Hflu prophylaxis, Leprosy, TB - mRNA synthesis inhibitor)

18

Ritonavir

Inhibitor (protease inhibitor)

19

St. Jon's Wort

inducer (Epinerphrine agonist

20

Sulfonamides

inhibtor (PABA inhibitor, prevents DHF synthesis)