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Flashcards in cytokines Deck (19):
1

cytokines secreted by macrophages

IL1, IL6, IL8, IL12, TNFalpha

2

cytokines secreted by all T-cells

IL2, IL3

3

cytokines secreted by Th1 cells

IFN-y

4

cytokines secreted by Th2 cells

IL4, IL5, IL10

5

role of Th1 cells

promotes cytotoxic pathway. Antihumoral defense. Stimulates granulomas, macrophage activation, CD8 cell activation

6

role of Th2 cells

promotes humoral immunity. Isotype switching.

7

antiinflammatory cytokines

IL10, IL13, TGF-B

8

IL1

pyrogen. Endothelium activation (LAD expression). Promotes differentiation of naive Th0 cells

9

IL6

pyrogen.

10

IL8

neutrophil chemotactic factor

11

IL12

induces Th1 cell differentiation. Activates NK cells. Secreted by B cells

12

TNFa

mediates septic shock = endothelium activation, vascular leakage, leukocyte recruitment.

13

IL2

Autocrine signal for all T-cells to grow and differentiation. Paracrine signal for B-cell, mpnocytes and NK cells to grow.

14

IL3

functiosn like GM-CSF - promotes bone marrow growth and differentiation

15

IFN-g

activates macrophages and TH1. increases expression of MHC I and II in all cells.

16

IL4

triggers Th2 cells to class switch to IgE and IgG

17

IL5

triggers isotype switchign to IgA. Stimulates eosinophil growth and differentiation

18

IL10

inhibits activation of T cells and Th1. Limits inflammatory cytokien production (TNFa, IL2, IL3, IFN-g)

19

IFN-alpha and beta

secreted as paracrine signal in response to viral infection. Stimualtes cell to make antiviral proteins (inhibit viral protein synthesis, and degrade viral RNA)