Flashcards in cytokines Deck (19):
cytokines secreted by macrophages
IL1, IL6, IL8, IL12, TNFalpha
cytokines secreted by all T-cells
cytokines secreted by Th1 cells
cytokines secreted by Th2 cells
IL4, IL5, IL10
role of Th1 cells
promotes cytotoxic pathway. Antihumoral defense. Stimulates granulomas, macrophage activation, CD8 cell activation
role of Th2 cells
promotes humoral immunity. Isotype switching.
IL10, IL13, TGF-B
pyrogen. Endothelium activation (LAD expression). Promotes differentiation of naive Th0 cells
neutrophil chemotactic factor
induces Th1 cell differentiation. Activates NK cells. Secreted by B cells
mediates septic shock = endothelium activation, vascular leakage, leukocyte recruitment.
Autocrine signal for all T-cells to grow and differentiation. Paracrine signal for B-cell, mpnocytes and NK cells to grow.
functiosn like GM-CSF - promotes bone marrow growth and differentiation
activates macrophages and TH1. increases expression of MHC I and II in all cells.
triggers Th2 cells to class switch to IgE and IgG
triggers isotype switchign to IgA. Stimulates eosinophil growth and differentiation
inhibits activation of T cells and Th1. Limits inflammatory cytokien production (TNFa, IL2, IL3, IFN-g)