CRP Flashcards

(46 cards)

1
Q

What is the function of C-reactive protein (CRP)?

A

CRP is an acute-phase protein that binds to self and extrinsic ligands

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are some self-ligands that CRP can recognize?

A

• Plasma lipoproteins
• Damaged cell membranes
• Several phospholipids
• Small nuclear ribonucleoprotein components
• Apoptotic cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are some extrinsic ligands that CRP can bind to?

A

• Phospholipids
• Capsular/cell body components

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are positive and negative acute-phase proteins (APPs)?

A

Positive APPs: Increase during inflammation
Negative APPs: Decrease during inflammation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

example of positive APPs

A

-C-reactive protein (CRP)
-Serum Amyloid A (SAA)
-Haptoglobin (Hp)
-Ceruloplasmin
-a2-Macroglobulin
-a1-Acid glycoprotein (AGP)
-Fibrinogen
-Complement (C3, C4)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what is an example of negative APPs

A

-Albumin
-Transferrin
-Transthyretin
-Retinol-binding protein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

NV of CRP

A

<10 mg/L

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What does an elevated CRP level indicate?

A

A higher CRP level suggests increased inflammation, which may be due to infection, autoimmune disease, or other inflammatory conditions.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Why is CRP not very specific?

A

CRP isn’t unique to one disease, so it cannot diagnose a specific condition but helps monitor inflammation and disease progression.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q
A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How is CRP useful in bacterial vs. viral infections?

A

An extremely elevated CRP suggests a bacterial infection, helping differentiate between bacterial and viral causes of illness.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

How can CRP levels help in patient management?

A

• Monitor disease progression
• Assess response to treatment
• Detect postoperative complications or new infections

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which interleukins are related to CRP production?

A

IL-1, 1L-6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Stimulates acute-phase protein production, including CRP

A

IL-6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Primary inducer of the inflammatory response

A

IL-1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

How do CRP and ESR compare?

A

CRP
- rapidly produced
- more sensitive
- more specific

ESR
- delayed response
- moderate sensitivity
- less specific

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

what are the functions of crp

A
  • anti infective
  • anti inflammatory actions
  • scavenging action
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

anti infective functions of crp

A
  • opsonization: makes particles for phagocytosis
  • activates complement (via classical pathway)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

anti inflammatory functions of crp

A
  • prevents systemic inflammation
  • release neutrophils while preventing white cell adhesion in non-inflamed tissue
20
Q

scavenging function of crp

A
  • does not bind to normal cell membrane
  • binds to apoptopic & necrotic cells
  • activates complement & attracts immune cells
21
Q

Processes induced by CRP

A
  • complement cascade activation
  • RAAS activation
  • prothrombotic state
  • endothelial dysfunction
  • opsonization of oxidized LDL
22
Q

CRP & Vascular wall damage

A
  • inflammatory cell infiltration
  • smooth muscle proliferation
  • increased sensitivity to proatherogenic factors
23
Q

CRP & Prothrombotic State

A
  • faster thrombin formation
  • increased adhesion molecules
  • decreased fibrolysis
24
Q

CRP & Endothelial dysfunction

A
  • decreased nitric oxide production
  • decreased vasodilation
  • glycocalyx damage
24
CRP & Oxidized LDL
- easier uptale by macrophages - foam cell formation (atherosclerosis risk)
24
effects of body mass in CRP levels
weight loss - decrease crp
24
effect of gender in CRP levels
higher in women
25
factors affecting CRP levels
- gender - body mass - ethnicity - exercise - alcohol
26
effects of ethnicity in CRP levels
higher in blacks
27
effects of exercise in CRP levels
lowers CRP
28
effects of alcohol in CRP levels
lowers CRP
29
methods for CRP detection
-ELISA -Immunoturbidimetry -Rapid Immunodiffusion -Visual Agglutination
30
clinical importance of CRP - elevated levels
- osteoarthritis - coronary events (esp in stable angina) - proinflammatory & prothrombotic effects
31
clinical importance of CRP - mild elevation
- SLE - Sclerodema - Sjogren's Syndrome - Dermatomyositis/Polymyositis
32
CRP & Antibiotic Therapy
CRP levels normalization = helpful tool in determining the response to antibiotic therapy and duration of treatment
33
elevated CRP levels can be seen in (transplants)
kidney & heart transplants
34
high CRP means possible?
GVHD
35
high CRP in cerebral vein thrombosis means
poor prognosis
36
thrombosis platelet count and CRP levels that have been found to be the strongest laboratory predictors of a **positive temporal artery biopsy**
CRP = >2.45 mg/dL Platelets = >400,000 uL
37
when does pancreatitis levels increase
3 days after pain onset
38
CRP level for pancreatitis that distinguishes mild from severe disease
150MG/L
39
more sensitive than CRP for cardiovascular injury
high sensitivity CRP (hs-CRP)
40
normal range for hs-crp
<0.3 mg/dL
41
hs-CRP uses
- predicts cardiovascular risk (CVD, stroke, PVD) - improves cholesterol based risk prediction - associated with hypotension risk
42
hs-crp is taken as an independent risk factor for ___, ____, ____
CVD, Stroke, and Peripheral vascular disease
43
hs-crp has been reporyed as a risk factor for?
hypotension