CSF Flashcards by Andrey Nalus

where is CSF produced

choroid plexus

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how much CSF is produced per hour in an adult

a. 10 mL
b. 15 mL
c. 20 mL
d. 25 mL

20 mL

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T or F. CSF resembles the plasma ultrafiltrate

false

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CSF

tube 1 is for:

chemistry and serology

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CSF

tube 2 is for:

microbiology

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CSF

tube 3 is for:

CM/hematology/cell counting

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CSF

tube 4 is for:

additional chemistry/serology/microbiology

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if testing will be delayed:

tube 1 should be stored at:

frozen temp

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if testing will be delayed:

tube 2 should be stored at:

room temp

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if testing will be delayed:

tube 3 should be stored at:

refrigerated temp

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if only 1 CSF tube can be collected, what test should be prioritized?

microbiology

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CSF appearance:

hazy, turbid, milky

microbes, protein

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CSF appearance:

oily

radiographic contrast media

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CSF appearance:

bloody

traumatic tap, rbcs

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CSF appearance:

xanthochromic

hemorrhage, bilirubin, hemoglobin, carotene

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CSF appearance:

clotted

BBB disorders, fibrinogen

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CSF appearance:

pellicle

BBB disorders, tubercle meningitis, clotting factors

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differentiate intracranial hemorrhage vs traumatic tap

traumatic tap - uneven blood distribution, has clot, not xanthochromic

when is the time RBC count is done in CSF?

to correct WBC count because of traumatic tap

T or F. CSF should be diluted first whether it is turbid or clear

False. if the sample is clear, no need for dilution

counting area for WBC count

4 WBC squares

CSF WBC proportion in adults

lymph 30

mono 70

CSF WBC proportion in children

lymph 70

mono 30

term for increased mononuclear count

pleocytosis

condition associated with pleocytosis with increased neutrophils

bacterial meningitis

condition associated with moderate pleocytosis with increased mononuclears

viral, tubercular, fungal, or parasitic meningitis

what type of WBC is seen in CSF if the patient has infection from Coccidioides immitis?

eosinophil

this WBC indicates previous hemorrhage

macrophage

these are degraded phagocytosed RBCs; stains dark-blue or black granules

hemosiderin granules

further degradation product, iron free

hematoidin crystals

cells that are seen in the epithelial lining of choroid plexus, no nucleoli

choroidal cells

seen in the lining of ventricles and neural canal, seen in clusters

ependymal cells

seen in the lining cells of arachnoid, also seen in systemic malignancies

spindle-shaped cells

these cells indicate dissemination from lymphoid tissues due to complication of acute leukemia

lymphoma cells

most frequently performed chemical test for the differentiation of meningitis

CSF protein

when CSF protein is higher than glucose, what kind of meningitis is present?

bacterial

CSF protein NV a. 35-55 b. 30-50 c. 15-45 d. 5-15

15-45

most abundant protein in CSF

albumin

second most abundant protein in CSF

prealbumin

two methods of CSF protein measurement

- nephelometry | - dye-binding

protein that is solely found in CSF

tau transferrin

to determine whether IgG production is within CNS or due to damaged blood-brain barrier

IgG index

indicates recent destruction of myelin | sheath (demyelination)

myelin basic protein