CSP

Question 1

A 57-year-old man has pulmonary TB due to Mycobacterium tuberculosis. His adherence with treatment has been poor and Mycobacterium tuberculosis has become resistant to rifampicin.

What is the typical mechanism for this resistance?

Enzymic destruction of the antibiotic molecule

Enzymic modification of the antibiotic molecule, by adding a small chemical group

Modification of the bacterial efflux pu

Modification of the bacterial pores

Modification of the bacterial RNA polymerase, the target of the drug

Answer 1

Modification of the bacterial RNA polymerase, the target of the drug

Question 2

A patient with a history of anaphylaxis to penicillin is to receive an antibiotic to be chosen from the following class of drug: penicillins, cephalosporins, carbapenems, monobactams and aminoglycosides.

Which class of drug can be administered safely without being at risk of causing an allergic reaction?

Aminoglycosides

Carbapenems

Cephalosporins

Monobactams

Penicillins

Answer 2

Aminoglycosides

Question 3

The main use for antidepressant agents is treating clinical depression. In addition, they are also used for other mental health conditions and treatment of long-term pain.

What is the principal mechanism of action of this type of agent?

Blocking epinephrine, serotonin reuptake pumps

Inhibition of the storage of serotonin and epinephrine in the vesicles of presynaptic nerve endings

Stabilisation of beta-adrenergic receptors

Stimulation of cholinergic receptors

Stimulation of norepinephrine receptors

Answer 3

Blocking epinephrine, serotonin reuptake pumps