Cutaneous Drug Eruptions Flashcards Preview

Dermatology > Cutaneous Drug Eruptions > Flashcards

Flashcards in Cutaneous Drug Eruptions Deck (30):
1

Roughly what percentage of adverse drug reactions are cutaneous

30%

2

The skin is a common target for what type of drug reactions

Idiosyncratic drug reactions

3

Why are drug reactions under reported

Not all patients with a reaction will go to their doctor

4

What is a type 1 allergic reactions

Urticaria

5

What is a type 2 reactions

Pemphigus and pemphigoid

6

What is a type 3 reactions

Purura/ Rash that can't be blanched

7

What is a type 4 reaction

T cell mediated. Erythema / rash

8

Immunologically -mediated reactions are dose dependent. True or False

False

9

Non-immunologically mediated reactions are dose dependent. True or false

True

10

Give some examples of non-immunologically mediated reactions

Eczema
Drug-induced alopecia (chemotherapy)
Phototoxicity
Psoriasis
Pigmentation
Cheilitis
Xerosis

11

A patient complains of burning/ tingling sensation when they are out in the sun. What is the diagnosis

Photosensitivity

12

How does a skin eruption usually resolve?

When the drug is withdrawn

13

Who is more at risk of developing a drug eruption? Males or females?

Females

14

What type of drugs are higher risks for drug eruptions

B lactam compounds, NSAIDS
High molecular weight/ hapten-forming drugs

15

What 3 things should be considered in a patient on multiple drugs?

A drug that is known to be most likely to cause an eruption
The time interval between exposure and development of skin reaction
History of previous exposure to the same drug

16

What is the most common type of drug eruption

Exanthematous

17

What type of reaction is an Exanthematous drug eruption

Type 4

18

Describe the usual appearance of an exanthematous drug eruption

Widespread symmetrically distributed rash
Pruritus and fever are also common

19

After how long does the reaction occur

4-21 days after first taking the drug

20

What are some indicators of a potentially severe reaction

Involvement of mucous membrane and face
Facial oedema and erythema
Widespread confluent erythema
Blisters
Shortness of breath
Wheezing

21

Name some drugs which are associated with Exanthematous drug eruptions

Penicillins
Sulphonamide antibiotics
Erythromycin
Streptomycin
Allopurinol
Anti-epileptics
NSAIDs
Phenytoin

22

Which immunoglobulin is usually associated with an Urticarial drug reaction

IgE (Type 1 )

23

Glucocorticoids can sometimes causes what type of drug eruption

Steroid acne
Pustular / Bullous drug eruption

24

What types of drugs can cause drug induced bullous pemphigoid

ACE inhibitors
Penicillin
Furosemide

25

Describe the apearance and locaation of fixed drug eruptions

Well demarcated round/ ovoid plaques.
Red, painful
Hands, genitalia, lips, oral mucosa (occcasionally)

26

What drugs are associated with fixed drug eruptions

Tetracycline, doxycycline
Paracetamol
NSAIDs
Carbamazepine

27

What type of light is usually a concern for phototoixc cutaneous drug reactions

UVA/ Visible

28

Name some drugs associated with phototoxicity

Antibiotics
Thiazidde diruetics
Chloropromazine
NSAIDs
Psoralens
Amiodarone
Immunosuppressants

29

What information about a drug reaction is required

The timing of symptoms to time of administration
When did the drug start/ stop
Photo of reaction
Why was the drug being taken
Drug history
Previous history of drug reactions/ allergy

30

What is the management for a patient with a drug reaction

Discontinue the drug is possible - use another one
Topical steroids may be useful
Antihistamines may be useful
Allergy bracelets
Report via the Yellow card scheme (medicines and healthcare products regulatory Agency)