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Flashcards in Pathology of Skin Deck (115)
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1

What is the peidermis mainly made up of

Maturing squamous cells

2

Where are melanocytes found

At the dermo-epidermal junction and in the basal layer

3

What is the ratio of melanocytes to basal cells

1:10

4

What is the granular layer rich in

Keratohyalin granules

5

What is the corneal layer made up of

Differentiated keratinised cells

6

What happens to corneocytes

They are shed from the surface and cause house dust

7

How is pigment shown

Melanocytes transfer pigment to keratinocytes via dendritic processes

8

Where are the Langerhan cells located

In the upper and mid-epidermis

9

Why are Langerhans cells important

In initiating inflammation

10

What is the difference in melanocytes in a pale skinned person compared to a darker skinned person

They have the same number of melanocytes but darker skinned people make more melanin

11

The matrix of the dermis is made up of what

Type 1 and type 3 collagen

12

What colour is a) collagen when and b) elastin when stained

Collagen is pink and elastin is blue

13

What is the ground substance of the dermis made up of

Hyaluronic acid and chondriotin sulphate

14

Describe the appearance and location of the papillary dermis

Thin and lies just beneath the epidermis

15

Describe the appearance and location of the reticular dermis

Thicker than the papillary dermis and contains type 1 collagen

16

What does the reticular dermis contain

Appendage structures - sweat glands, pilosebaceous units

17

What is the epidermal Basment Membrane made of

laminin and collagen IV

18

What type of cells appear to have halos around them

Melanocytes

19

What is parakeratosis

Persistence of nuclei in the keratin layer - the skin turnover is too high

20

Define papillomatosis

irregular epithelial thickening

21

Give an example of papillomatosis

Acanthiosis nigricans

22

What are the 4 main reaction patterns of inflammatory skin diseases

Spongiotic-intraepidermal oedema (eczema)
Psoriasiform-elongation of the rete ridges (psoriasis)
Lichenoid-basal layer damage (pemphigoid, pemphigus and dermatitis herpetiformis)

23

What are Munro micro abscess

A collection of neutrophils and classsically psoriasis

24

Where are 3 common sites of acne

Face
Upper back
Anterior chest

25

What are open comedones

Blackhead since it is oxidised

26

What causes a yellow head

A build up of Sebum and keratine cloggasge

27

Describe the aetiology of acne

Increased androgens at puberty, increased angrogen sensitivity of sebaceious glands
keratin plugging of pilosebaceious units
infection with anaerobic bacterium corynebacterium acnes

28

Rosacea is more common in females than males. true or false

True

29

What are some common features of rosacea

Recurrent facial flushing
Visible blood vessels
Pustules
Thickening of skin - rhinophyma

30

What are some triggers of rosacea

Sunlight
Alcohol
Spicy foods
Stress