CV Autonomic Pharmacology Flashcards
What do these do? Propranolol Metoprolol Phentolamine Prazosin Carvadilol
sympatholytics (block)
What do these do? Norepinephrine Epinephrine Isoproterenol Dobutamine Dopamine Phenylephrine Clonidine Tyramine
sympathomimetics
What do these do?
Acetycholine
Digoxin?
cholinomimetics (parasympathetic agonists)
What do these do?
Atropine
Trimethaphan
cholinolytics (block)
What type of receptors are found in smooth muscle (blood vessels, eye, gut, bladder)?
alpha 1
What type of receptors cause Formation of IP3 (increase intracellular Ca2+), DAG (activate PKC)?
alpha 1
What type of receptors are found in presynaptic nerve terminals, smooth muscle (blood vessels)
alpha 2
What type of receptors cause inhibition of neuronal Ca2+ channels; inhibition of adenylyl cyclase (decrease cAMP)
alpha 2
What type of receptors are found in cardiac myocytes, juxtaglomerular cells (kidney)
beta 1
What type of receptors cause Stimulation of adenylyl cyclase, increased cAMP
beta 1, beta 2, beta 3
What type of receptors are found in smooth muscle (airways, blood vessels), ciliary body epithelium (eye), cardiac muscle
Beta 2
What type of receptors are found in adipocytes?
beta 3
What type of muscarininc receptors are found in cardiac muscle?
M2
What type of muscarinic receptor Activate K+ channels (hyperpolarization), inhibit adenylyl cyclase (decrease cAMP)?
M2
*Sinoatrial node
Sympathetic activation of β1 adrenergic receptors has a (blank) effect
Parasympathetic activation of M2 muscarinic receptors has a (blank) effect
positive chronotropic effect (increases heart rate) negative chronotropic effect (decreases heart rate)
*Atrioventricular node
Sympathetic activation of β1 adrenergic receptors has a (blank) effect.
Parasympathetic activation of M2 muscarinic receptors has a (blank) effect
positive dromotropic effect (increases conduction velocity)
negative dromotropic effect (decreases conduction velocity)
*Ventricular muscle
Sympathetic activation of β1 adrenergic receptors has a (blank) effect
Parasympathetic activation of M2 muscarinic receptors (blank) sympathetic responses. In the absence of sympathetic tone, parasympathetic activation has little or no effect on the ventricles.
positive inotropic effect (increases contractility)
antagonizes
*Blood Vessels
Sympathetic activation
α1 adrenergic receptors cause (blank)
β2 adrenergic receptors cause (blank)
vascular smooth muscle contraction and constriction of blood vessels.
relaxation of vascular smooth muscle and dilation of blood vessels.
(blank) activation has little or no effect on most blood vessels. Exceptions include blood vessels of the face, tongue, genitals and urinary tract, where (blank) stimulation causes relaxation of the vascular smooth muscle and vasodilation.
Parasympathetic
Parasympathetic
(blank) mostly just helps with total peripheral resistance with blood vessels.
parasympathetics
What is a non-selective antagonist for A1, A2, B1, B2, D1?
carvedilol
What is a selective antagonist for alpha 1 receptors?
prazosin
What is a selective antagonist for alpha 2 receptors?
yohimbine
What is nonselective agonist of alpha receptors?
oxymetazoline
What is a selective agonist for alpha 1 receptors?
phenylephrine
What is a selective agonist for alpha 2 receptors?
clonidine
What is a nonselective agonist for beta receptors?
isoproterenol
What is a selective agonist for beta 1 receptors?
dobutamine
What is a selective agonist for beta 2 receptors?
terbutaline
What is a selective agonist for D1 receptors?
fenoldopam
B2 receptors are more susceptible to (blank)
epinephrine
Norepinephrine is more susceptible to (blank)
beta 1 and alpha 1 receptors
Which would you want to utilize more for vasoconstrction and dilation; epinephrine or norepinephrine?
epinephrine
Norepinephrine likes the 1 receptors or the 2’s?
the 1’s
Does epinephrine have a higher affinity for betas or alphas?
betas
Does isoproterenol have more of an affinity for alphas or betas?
betas
Does phenylephrine have more of an affinity for a’s or b’s and 1 or 2?
alpha 1 then alpha 2
Does clonidine like alpha or betas better and 1 or 2?
alpha 2 then alpha 1
What do you use for:
severe hypotension; septic shock
norepinephrine
What do you use for:
anaphylactic shock; cardiogenic shock; cardiac arrest; local vasoconstriction
Epinephrine
What do you use for:
cardiogenic shock; bradycardia; atrioventricular block
isoproterenol
What do you use for:
acute heart failure; cardiogenic shock
dobutamine
What do you use for:
acute heart failure; cardiogenic shock; acute renal failure
dopamine
What do you use for:
topical vasoconstriction; shock; autonomic testing
phenylephrine
What do you use for:
hypertension
clonidine
(blank) is a life-threatening condition that occurs when the body is not getting enough blood flow.
shock
What are the major classes of shock?
hypovolemic, cardiogenic,vasodilatory
What is shock due to weakened heart?
cardiogenic
What is shock do to lack of blood?
hypovolemic
What is shock such as septic or anaphylaxic due to vasodilation?
vasodilatory shock
(blank) causes an increase in diastolic and systolic pressure, increase in MAP, increase in SV, PP but decrease in heart rate, increase TPR.
norepinephrine
What is the equation for CO?
Co=MAP/TPR