CV Development Flashcards

1
Q

What are the four heart fields when referring to the tissues that give rise to the heart?

A

Primary (cardiac crescent) - endocardium, myocardium

Secondary - contributes to arterial and venous ends

Tertiary (proepicardium) - gives rise to epicardium, coronary arteries, fibroblasts

Quaternary (cardiac neural crest) - smooth muscle of great vessels, parasympathetic neurons

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2
Q

On what days does septation occur?

A

Days 25-28

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3
Q

Which pharyngeal arches does neural crest travel through to form the bulbar and truncal ridges?

A

3, 4, and 6

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4
Q

What day are the septum primum and foramen primum formed, approximately?

A

Day 28

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5
Q

Around what days is the foramen secundum formed?

A

Days 32-35

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6
Q

When is the atrial septation finished by with the septum secundum and foramen ovale functioning?

A

5th-8th weeks

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7
Q

When do the pharyngeal arch arteries form? When do their derivatives form?

A

4th week. 8th week

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8
Q

What is the fate of the third pharyngeal arch artery?

A

Becomes the common carotid arteries

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9
Q

What is the fate of the 4th pharyngeal arch artery?

A

Right: base of the subclavian artery

Left: aortic arch between the common carotid and subclavian arteries

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10
Q

What is the fate of the 6th pharyngeal arch artery?

A

Right: pulmonary artery

Left: pulmonary artery and ductus arteriosus

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11
Q

What do the vitelline veins become?

A

Hepatic portal system, hepatic sinusoids, SMV, first part of IVC

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12
Q

What does the umbilical vein become?

A

Ductus venosus, ligamentum venosum within the liver, ligamentum teres (of the liver) outside of the liver

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13
Q

What do the anterior cardinal veins become?

A

Brachiocephalic veins, jugular veins, subclavian veins

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14
Q

What do the subcardinal veins become?

A

3rd part of IVC, renal veins, gonadal veins

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15
Q

What do the supracardinal veins become?

A

Azygous system and lumbar veins

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16
Q

What do the sacrocardinal veins become?

A

Common iliac veins, external/internal iliac veins, 5th part of IVC

17
Q

What do the common cardinal veins become?

A

SVC

18
Q

What causes the ductus arteriosus to collapse?

A

Bradykinins, prostaglandins E1 and prostacyclins

19
Q

What is the most common type of congenital heart defect? What can cause this?

A

Ventricular septal defects. Failure of the IV muscular/membranous ridges to align with the bulbar ridges and AV cushions

20
Q

What is the most common atrial septal defect? What are the 4 clinically significant ASDs?

A

Patent foramen ovale. Ostium secundum, ostium primum w/ endocardial cushion defect, sinus venosus defect, common atrium

21
Q

What defect is caused by the failure of the spiral septum to form? What is a symptom?

A

Transposition of the great arteries. Cyanosis

22
Q

What is persistent truncus arteriosus? What is a symptom?

A

Failed septation of the truncus arteriosus into the aorta and pulmonary trunk. Cyanosis