cytogen history Flashcards
_____________ published his investigations into inheritance of pea plants
Gregor Mendel 1865/ 1866
_____________ suggested that chromosomes are involved with inheritance
Theodor Boveri 1890
observed chromosomes in grasshopper cells
Walter Sutton 1900
discovered that some diseases must be inherited
Archibald Garrod 1902
_______________, working independently, suggested that each egg of sperm cell contains only one of each chromosome pair
Sutton and Boveri 1903
________________ and _______________, working independently, proposed that certain
chromosomes determine sex. They show that a single Y chromosome determines maleness, and two
copies of the X chromosome determine femaleness
Edmund Beecher Wilson & Nettie Stevens 1905
_____________ gave the term ‘genetics’
Bateson 1906
____________________ used the term ‘gene’ to describe the carrier of heredity, ‘genotype’ to describe
an organism’s genetic make-up, and ‘phenotype’ to describe an organism’s outward appearance
Wilhelm Johannsen 1909
____________________ proved that genes are carried on chromosomes. He also showed that some characteristics are carried on the sex chromosome
Thomas Hunt Morgan 1910
_____________________ mapped the genes of the fruit fly’s sex chromosome
Alfred Henry Sturtevant 1911/1913
________________ and his son discover that X-rays can be used to study the molecular
structure of simple crystals, such as salt
Sir William Henry Bragg 1912
__________________ published the ‘Theory of the Gene’
Morgan 1926
_____________________discovered ‘transformation’ in bacteria
Frederick Griffith 1928
______________, _______________, and __________________ used bacteria to show that DNA is the hereditary material
Oswald Avery, Colin MacLeod, Maclyn Mccatty 1944
_________________________ finds that the amounts of adenine and thymine in DNA are about the same, as area the amounts of guanine and cytosine
Edward Chargaff 1949
________________ and __________________ proposed that the DNA molecule is a double-stranded helix
James Watson & Francis Crick 1953
______________ published the ‘Theory of the Gene’
Morgan 1926
____________________ and ________________ work out the genetic code
Marshall Nirenberg & Heinrich Matthaei 1963-1966
DNA from virus is sequenced for the first time by ____________________, _____________________ and _____________________, working independently
Frederick Sanger, Walter Gilbert, Allan Maxam 1977
____________________ discovered the Polymerase Chain Reaction (PCR), enabling lengths of DNA to be multiplied
Kary Mullis 1983
___________________, ______________________, and _______________ analyze mitochondrial DNA in different human races.
They declared that humans have a common ancestor who lived 200,000 years ago
Rebecca Cann, Mark Stoneking, Allan Wilson 1987
The first Human gene is sequences by ________________ and _______________. It is the gene that cause
cystic fibrosis
Francis Collins & Lap-chee Tsui 1989
The Human Genome Project is launched
1990
Cystic fibrosis became the first genetic disease to be treated using gene therapy
1993
