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IBI Test I > Cytokines > Flashcards

Cytokines Flashcards

1
Q

TNF-a is secreted by

A

macrophages

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2
Q

TNF-a induces ______ via signaling at hypothalmic nuclei

A

fever

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3
Q

TNF-a promotes _______

A

inflammation

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4
Q

TNF-a works synergistically with _____ and ______ to induces the SIRS response

A

IL-1 and IL-6

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5
Q

TNF-a, IL-1, and IL-6 cause the hepatic release of which acute phase reactants?

A

CRP and fibrinogen

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6
Q

activates endothelium to increase vascular leak and causes WBC recruitment

A

TNF-a

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7
Q

Causes cachexia

A

TNF-a

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8
Q

IL-1 is secreted by

A

macrophages

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9
Q

pyrogen

A

IL-1

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10
Q

produces PGE2, which acts on hypothalmic nuclei

A

IL-1

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11
Q

activates endothelium to express adhesion molecules

A

IL-1

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12
Q

induces chemokine secretion to recruit WBCs

A

IL-1

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13
Q

promotes vasodilation and capillary permeability

A

IL-1

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14
Q

secreted by Helper T Cells (Th1)

A

IL-2

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15
Q

stimulates growth of all lymphocytes

A

IL-2

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16
Q

first cytokine produced by T cells after activation

A

IL-2

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17
Q

helps to amplify adaptive immune response

A

IL-2

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18
Q

stimulates NK cells

A

IL-2

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19
Q

secreted by all Helper T cells

A

IL-3

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20
Q

supports growth and differentiation of bone marrow stem cells

A

IL-3

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21
Q

secreted by Th2 cells

A

IL-4; IL-5; IL-10

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22
Q

induces differentiation of Th2 cells

A

IL-4

23
Q

works in an autocrine fashion to amplify Th2 response

A

IL-4

24
Q

enhances B cell growth

A

IL-4

25
Q

enhances class switching to IgE

A

IL-4

26
Q

stimulates growth and differentiation of eosinophils

A

IL-5

27
Q

important in defense against parasitic infections

A

IL-5

28
Q

enhances class switching to IgA

A

IL-5

29
Q

IL-6 is secreted by

A

macrophages

30
Q

IL-6 causes ______ via PGE2

A

fever

31
Q

IL-6 promotes ________ via vasodialtion

A

inflammation

32
Q

IL-8 is secreted by

A

macrophages

33
Q

chemotaxis of neutrophils

A

IL-8

34
Q

anti-inflammatory cytokine

A

IL-10

35
Q

important for wound healing

A

IL-10

36
Q

inhibits production of TNF-a, IFN-y, IL-2

A

IL-10

37
Q

decreases expression of MCH II and Th1

A

IL-10

38
Q

inhibits activation of macrophages and dendritic cells

A

IL-10

39
Q

IL-12 is secreted by

A

macrophages

40
Q

promotes defense against intracellular pathogens

A

IL-12

41
Q

promotes differentiation of Th1 cells

A

IL-12

42
Q

activates NKs

A

IL-12

43
Q

TGF-b is secreted by

A

most cells in the body

44
Q

major anti-inflammatory cytokine and growth factor

A

TGF-b

45
Q

implicated in formation of scar tissues

A

TGF-b

46
Q

produced via leukocytes and virally infected cells

A

IFN-a, IFN-b

47
Q

slows viral replication by halting protein synthesis

A

IFN-a, IFN-b

48
Q

degrades mRNA in virally infected cells

A

IFN-a, IFN-b

49
Q

used in the treatment of viral infections

A

IFN-a, IFN-b

50
Q

secreted by Th1 and NKs

A

IFN-y

51
Q

activates macrophages

A

IFN-y

52
Q

involved in phagocytosis of granuloma

A

IFN-y

53
Q

creates a reinforcing feedback loop, since macrophages produce IL-12 to stimulate Th1 cells

A

IFN-y

IBI Test I (18 decks)

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