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IBI Test I > DNA viruses > Flashcards

DNA viruses Flashcards

1
Q

are herpesviruses enveloped?

A

yes

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2
Q

do herpesviruses have a linear or circular chromosome?

A

linear

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3
Q

what kind of virus are herpesvirus?

A

dsDNA

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4
Q

herpesviruses replicate using

A

DNA dependent DNA polymerase

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5
Q

how to herpesviruses get their membrane?

A

budding from the nuclear membrane of host cell

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6
Q

transmission: HSV1

A

contact with infected lesions

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7
Q

grouped vesicles on erythematous base

A

HSV-1, HSV-2

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8
Q

gingivostomatitis

A

HSV-1

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9
Q

herpetic whitlow

A

HSV-1

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10
Q

where does HSV1 establish dormancy?

A

trigeminal ganglia

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11
Q

how do herpesviruses reactivate?

A

anterograde transport to epithelial cells

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12
Q

herpes labialis, erythema multiforme, keratoconjuctivitis

A

HSV-1

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13
Q

temporal lobe encephalitis

A

HSV1

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14
Q

“punched out” ulcers on endoscopy

A

HSV-1

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15
Q

diagnosis: HSV1/HSV-2

A

PCR/viral culture is gold standard
Tzank smear for multinucleated giant cells

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16
Q

Cowdry bodies

A

HSV-1, HSV-2

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17
Q

Treatment: HSV-1/HSV-2

A

acyclovir, valacyclovir

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18
Q

transmission HSV2

A

sexual contact, perinatal contact

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19
Q

herpes genitalis

A

HSV2

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20
Q

HSV2 establishes dormancy in

A

sacral ganglia

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21
Q

how do herpesviruses establish dormancy?

A

enter sensory nerve and move via retrograde transport into gangle

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22
Q

viral meningitis

A

HSV2

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23
Q

HHV3 aka

A

VZV

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24
Q

transmission HHV3

A

respiratory droplet
direct contact with infected lesions

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25
Q

VZV replicates in

A

T cells

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26
Q

Chickenpox

A

vesicular rash caused by VZV (HHV3)

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27
Q

primary infection of _________ in immunocompromised can cause encephalitis and pneumonia

A

VZV (HHV3)

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28
Q

where does VZV establish latency?

A

dorsal root ganglia

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29
Q

shingles affects a single __________

A

dermatome

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30
Q

shingles is often complicated by

A

post herpetic neuralgia

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31
Q

shingles causes a ____________ nerve pain

A

burning/stabbing

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32
Q

Shingles nerve pain usually ___________ the rash

A

preceeds

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33
Q

Ramsay-Hunt syndrome

A

otitis/facial paralysis caused by VZV

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34
Q

blindess due to VZV is caused by

A

CN V1 branch involvment

35
Q

blindness due to VZV is called

A

herpes zoster ophthalmicus

36
Q

Treatment: shingles

A

famciclovir, valacyclovir
analgesics to control nerve pain

37
Q

diagnosis: VZV

A

PCR is gold standard
Tzank smear

38
Q

why is a Tzank smear outdated?

A

poor sensitivity/specificity

39
Q

HHV4 aka

A

EBV

40
Q

EBV is common in

A

teens, young adults

41
Q

EBV is transmitted through

A

saliva

42
Q

EBV infects B cells through

A

CD21

43
Q

EBV establishes latency in

A

B cells

44
Q

monospot positive

A

EBV

45
Q

classic mononucleosis presentation

A

pharyngitis
lymphadenopathy
splenomegaly

46
Q

Burkitt lymphoma

A

EBV

47
Q

nasopharyngeal carcinomas

A

EBV

48
Q

oral hair luekoplakia

A

EBV

49
Q

morbilliform rash after penicillin

A

EBV

50
Q

atypical lymphocytes

A

EBV

51
Q

transmission: CMV

A

transplants, through placenta, close contact, sexual exposure

52
Q

retinitis, colitis, linear esophagitis

A

CMV

53
Q

post transplant patient are at high risk for _____ pneumonia

A

CMV

54
Q

CMV aka

A

HHV5

55
Q

congentital CMV is associated with

A

sensorineural hearing loss

56
Q

histopath: CMV

A

owl’s eyes inclusions

57
Q

negative monospot

A

CMV

58
Q

treatment: CMV

A

gancicolvir/valganciclovir

59
Q

cotton wool exudates

A

CMV retinitis

60
Q

roseola

A

HHV-6/7

61
Q

what ages does roseola affect?

A

6-24 months

62
Q

roseola is characterized by

A

high fever for 3-5 days followed by maculopapular rash that starts on the neck and spreads out to extremities

63
Q

HHV8 causes _________ in HIV patients

A

Kaposi Sarcoma

64
Q

HHV8 inhibits

A

tumor suppression pathway

65
Q

HHV-8 causes what kind of rash

A

discolored skin lesions: blue/red/violet/purple

66
Q

Poxvirus replicates in the ______

A

cytoplasm

67
Q

largest DNA virus

A

poxvirus

68
Q

is the poxvirus enveloped?

A

yes

69
Q

what kind of genetic material is in the poxvirus?

A

DS linear DNA

70
Q

is the adenovirus enveloped?

A

no

71
Q

what kind of genetic material is in the adenovirus?

A

DS linear DNA

72
Q

what kind of genetic material is in the papillomavirus?

A

DS circular DNA

73
Q

what kind of genetic material is in the polyomavirus?

A

DS circular DNA

74
Q

what kind of genetic material is in the parvovirus?

A

SS linear DNA

75
Q

what is the smallest DNA virus?

A

parvovirus

76
Q

causes a “slapped cheek” rash in children

A

parvovirus

77
Q

fifth disease

A

parvovirus

78
Q

is the adenovirus enveloped?

A

no

79
Q

what kind of genetic material is in the hepadnavirus?

A

DS circular DNA

80
Q

is the hepadnavirus enveloped?

A

yes

81
Q

hepadnaviruses use _____ to replicate

A

reverse transcriptase

82
Q

is the papillomavirus enveloped?

A

no

83
Q

is the polyoma viruse enveloped?

A

no

84
Q

is the parvovirus enveloped?

A

no

IBI Test I (18 decks)

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