Innate Immunity Flashcards
1
Q
TLR-1, TLR-2, TLR-6
A
bacterial lipopeptides
2
Q
TLR-2
A
bacterial lipopeptides and peptidoglycan
3
Q
TLR-4
A
LPS
4
Q
TLR-5
A
bacterial flagellin
5
Q
TLR-3
A
dsRNA
6
Q
TLR-7
A
ssRNA
7
Q
TLR-8
A
ssRNA
8
Q
TLR-9
A
CpG DNA
9
Q
NOD-1, NOD-2
A
recognizes bacterial peptidoglycan
activate NF kB
10
Q
NLRP-3
A
recognizes microbial products
enhances productions of IL-1B
11
Q
Inflammasome
A
NLRP-3 oligomerizes with caspase 1to form
activates caspase 1
12
Q
active caspase 1
A
cleaves pro-IL-1B
13
Q
inflammasome dysregulation causes
A
gout
auto-inflammatory syndromes
14
Q
Lysozyme
A
degrades the peptidoglycan layer of bacterial cell walls
15
Q
defensins and cathelicidans
A
leukocyte cytoplasmic granules containing cationic antimicrobial peptides
fuse with phagolysosome to disrupt the membrane functions of microorganisms
