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Cytokines Flashcards

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1
Q

IL-10 secreted by

A
  1. Th2 cells
  2. TReg Cells
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2
Q

IL-6 secreted by

A
  1. Monocytes
  2. Macrophages
  3. Th2 cells
  4. BM Stromal cells
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3
Q

IL-3 target cell/tissue

A

Hematopoietic cells (myeloid)

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4
Q

Interferon-γ (type 2) activity on Macrophages

A

Enhances activity

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5
Q

IL-6 activity on Hepatocytes

A

Induces synthesis of Acute-phase proteins

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6
Q

IL-4 activity on Antigen-primed B cells

A

Costimulates activation

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7
Q

IL-6 activity on Proliferating B cells

A

Promotes terminal differntiation into Plasma Cells

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8
Q

TNF-α target tissue/cells

A

Tumor cells

Inflammatory cells

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9
Q

IL-12 activity on NK and LAK and activated Th1 cells

A

Stimulats proliferation

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10
Q

IL-6 target cell/tissue

A
  1. Proliferating B cells
  2. Plasma cells
  3. Myeloid Stem cells
  4. Hepatocytes
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11
Q

IL-2 target cell/tissue

A

Antigen-primed Th and CTLs

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12
Q

Interferon-β (type 1) target cell/tissue

A

Unifected cells

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13
Q

IL-13 secreted from

A

Th2 Cells

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14
Q

IL-17 target tissue/cells

A
  1. Fibroblasts
  2. Endothelial cells
  3. Macrophages
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15
Q

Interferon-γ (type 2) activity on Phagocytic cells

A

Mediates effects important in DTH

Treatment of CGD

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16
Q

IL-7 target cell/tissue

A

Lymphoid stem cells

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17
Q

TGF-β activity

A

Induces class switching to IgA

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18
Q

TNF-β activity on Tumor cells

A

Cytotoxic

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19
Q

IL-2 secreted by

A

Th cells

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20
Q

IL-4 secreted by

A

Th2 cells

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21
Q

IL-17 secreted from

A

Th17 cells

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22
Q

IL-1 Secreted by

A
  1. Monocytes
  2. Macrophages
  3. B cells
  4. Dendritic cells
  5. Endothelial cells
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23
Q

G-CSF target tissue/cell

A

BM granulocyte precursors

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24
Q

TNF-α activity on tumor cells

A

Cytotoxic effects

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25
Interferon-γ (type 2) secreted by
1. Th1 cells 2. CTLs 3. NK cells
26
Interferon-β clinical use
MS
27
G-CSF secreted by
Macrophages and Th cells
28
IL-1 activity on B cells
Promotes maturation and clonal expansion
29
Interferon-γ (type 2) activity on Th2 cells
Inhibits proliferation
30
IL-1 activity on Hypothalamus
Induces fever
31
TNF-β target tissue/cells
Tumor cells Macrophages and PMN
32
IL-13 target tissue/cell
B cells
33
IL-1 activity on Endothelial cells
Increases expression of ICAMs
34
IL-12 activity on Activated CD8 cells
Acts synergistically with IL-2 to induce differentiation into CTLs
35
IL-5 activity on BM cells
Induces Eosinophil differentitiation
36
IL-6 activity on Myeloid stem cells
Helps promote differentiation
37
IL-5 activity on Activated B cells
Stimulates proliferation and differentiation Induces class swithing to **IgA**
38
IL-1 activity on Hepatocytes
Induces synthesis of acute-phase proteins
39
TGF-β secreted by
1. Platelets 2. Macrophage 3. Lymphocytes 4. Mast cells
40
Interferon-β (type 1) activity
Inhibits viral replication
41
Sargramostim
GM-CSF analog
42
IL-5 target cell/tissue
1. Activated B cells 2. BM cells
43
IL-7 secreted by
1. BM 2. Thymic stromal cells
44
IL-1 activity on TH cells
Costimulates activation
45
Aldesleukin clincal uses
**IL-2** Increase lymphocyte differentiation and increase NK Used in **RCC and Metastatic Melanoma**
46
IL-2 activity
Induces proliferation and enhances activity of Th and CTLs
47
IL-3 secreted by
Th cells NK cells
48
IL-5 secreted by
Th2 Cells and mast cells
49
TNF-α secreted by
Macrophages NK cells
50
IL-11 activity
Increase platelet count
51
IL-6 activity on Plasm acells
Stimulates Ab secretion
52
IL-4 activity on activated B cells
Stimulates proliferation, induces class swithing to **IgE**
53
IL-12 secreted by
Macrophages B cells
54
TNF-β secreted by
Th1 cells CTL
55
Interferon-α (type 1) target tissue/cells
Uninfected cells
56
IL-11 target cell/tissue
BM
57
TNF-α activity on inflammatory cells
induces cytokine secretion causing **cachexia of chronic inflammation**
58
TNF-β activity on Macrophages and PMN
Enhances phagocytic activity
59
IL-4 target cell/tissue
1. Antigen-primed B cells 2. Activated B cells
60
GM-CSF secreted by
Macrophages and Th cells
61
IL-1 activty on NK cells
Enhance activity
62
IL-1 target cells/tissue
1. Th cells 2. B cells 3. NK cells 4. Endothelial cells 5. Macrophage and PMN 6. Hepatocytes 7. Hypothalamus
63
IL-13 activity
Induces Isotype switch to **IgE**
64
IL-11 secreted by
BM stroma
65
Interferon-γ (type 2) target cell/tissue
1. Macrophage 2. All cell types 3. Proliferating B cells 4. Th2 cells 5. Phagocytic cells
66
Interferon-α (type 1) activity
Inhibits viral replication
67
IL-10 activity
Suppressess cytokine production by Th1 cells
68
Interferon-α clinical uses
1. Hap B and C 2. Leukemia 3. Melanoma
69
IL-10 target cell/tissue
Macrophages
70
TGF-β target tissue/cells
Proliferating B cells
71
IL-12 target tissue/cells
1. Activated CD8 2. NK and LAK cells 3. Activated Th1
72
IL-17 activity
1. Increase inflammation 2. Attract PMNs 3. Induces IL-6, IL-1, TGFβ, TNFα, and IL-8 4. Role in Autoimmune disease and Allergy
73
Interferon-γ clinical use
CGD by increasing TNF
74
IL-3 activity
Supports growth and differentiation of Myeloid cells
75
Filgrastim
G-CSF analog
76
IL-1 activity on Macrophages and PMN
Chemotactically attracts
77
IL-7 activity
Induces differentiation into progenitor B and T cells
78
Interferon-β (type 1) Secreted by
Fibroblasts
79
GM-CSF target tissue/cell
BM granulocyte and macrophage precursors
80
Interferon-α (type 1) secreted by
Leukocytes
81
Interferon-γ (type 2) activity on proliferating B cells
Induces class swiching to **IgG2a** Blocks **IL-4** induced class swtiching to **IgE and IgG1**

Immunology (11 decks)

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