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Immunology > Cytokines > Flashcards

Cytokines Flashcards

1
Q

IL-10 secreted by

A
  1. Th2 cells
  2. TReg Cells
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2
Q

IL-6 secreted by

A
  1. Monocytes
  2. Macrophages
  3. Th2 cells
  4. BM Stromal cells
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3
Q

IL-3 target cell/tissue

A

Hematopoietic cells (myeloid)

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4
Q

Interferon-γ (type 2) activity on Macrophages

A

Enhances activity

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5
Q

IL-6 activity on Hepatocytes

A

Induces synthesis of Acute-phase proteins

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6
Q

IL-4 activity on Antigen-primed B cells

A

Costimulates activation

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7
Q

IL-6 activity on Proliferating B cells

A

Promotes terminal differntiation into Plasma Cells

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8
Q

TNF-α target tissue/cells

A

Tumor cells

Inflammatory cells

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9
Q

IL-12 activity on NK and LAK and activated Th1 cells

A

Stimulats proliferation

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10
Q

IL-6 target cell/tissue

A
  1. Proliferating B cells
  2. Plasma cells
  3. Myeloid Stem cells
  4. Hepatocytes
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11
Q

IL-2 target cell/tissue

A

Antigen-primed Th and CTLs

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12
Q

Interferon-β (type 1) target cell/tissue

A

Unifected cells

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13
Q

IL-13 secreted from

A

Th2 Cells

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14
Q

IL-17 target tissue/cells

A
  1. Fibroblasts
  2. Endothelial cells
  3. Macrophages
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15
Q

Interferon-γ (type 2) activity on Phagocytic cells

A

Mediates effects important in DTH

Treatment of CGD

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16
Q

IL-7 target cell/tissue

A

Lymphoid stem cells

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17
Q

TGF-β activity

A

Induces class switching to IgA

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18
Q

TNF-β activity on Tumor cells

A

Cytotoxic

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19
Q

IL-2 secreted by

A

Th cells

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20
Q

IL-4 secreted by

A

Th2 cells

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21
Q

IL-17 secreted from

A

Th17 cells

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22
Q

IL-1 Secreted by

A
  1. Monocytes
  2. Macrophages
  3. B cells
  4. Dendritic cells
  5. Endothelial cells
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23
Q

G-CSF target tissue/cell

A

BM granulocyte precursors

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24
Q

TNF-α activity on tumor cells

A

Cytotoxic effects

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25
Q

Interferon-γ (type 2) secreted by

A
  1. Th1 cells
  2. CTLs
  3. NK cells
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26
Q

Interferon-β clinical use

A

MS

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27
Q

G-CSF secreted by

A

Macrophages and Th cells

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28
Q

IL-1 activity on B cells

A

Promotes maturation and clonal expansion

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29
Q

Interferon-γ (type 2) activity on Th2 cells

A

Inhibits proliferation

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30
Q

IL-1 activity on Hypothalamus

A

Induces fever

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31
Q

TNF-β target tissue/cells

A

Tumor cells

Macrophages and PMN

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32
Q

IL-13 target tissue/cell

A

B cells

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33
Q

IL-1 activity on Endothelial cells

A

Increases expression of ICAMs

34
Q

IL-12 activity on Activated CD8 cells

A

Acts synergistically with IL-2 to induce differentiation into CTLs

35
Q

IL-5 activity on BM cells

A

Induces Eosinophil differentitiation

36
Q

IL-6 activity on Myeloid stem cells

A

Helps promote differentiation

37
Q

IL-5 activity on Activated B cells

A

Stimulates proliferation and differentiation

Induces class swithing to IgA

38
Q

IL-1 activity on Hepatocytes

A

Induces synthesis of acute-phase proteins

39
Q

TGF-β secreted by

A
  1. Platelets
  2. Macrophage
  3. Lymphocytes
  4. Mast cells
40
Q

Interferon-β (type 1) activity

A

Inhibits viral replication

41
Q

Sargramostim

A

GM-CSF analog

42
Q

IL-5 target cell/tissue

A
  1. Activated B cells
  2. BM cells
43
Q

IL-7 secreted by

A
  1. BM
  2. Thymic stromal cells
44
Q

IL-1 activity on TH cells

A

Costimulates activation

45
Q

Aldesleukin clincal uses

A

IL-2

Increase lymphocyte differentiation and increase NK

Used in RCC and Metastatic Melanoma

46
Q

IL-2 activity

A

Induces proliferation and enhances activity of Th and CTLs

47
Q

IL-3 secreted by

A

Th cells

NK cells

48
Q

IL-5 secreted by

A

Th2 Cells and mast cells

49
Q

TNF-α secreted by

A

Macrophages

NK cells

50
Q

IL-11 activity

A

Increase platelet count

51
Q

IL-6 activity on Plasm acells

A

Stimulates Ab secretion

52
Q

IL-4 activity on activated B cells

A

Stimulates proliferation, induces class swithing to IgE

53
Q

IL-12 secreted by

A

Macrophages

B cells

54
Q

TNF-β secreted by

A

Th1 cells

CTL

55
Q

Interferon-α (type 1) target tissue/cells

A

Uninfected cells

56
Q

IL-11 target cell/tissue

A

BM

57
Q

TNF-α activity on inflammatory cells

A

induces cytokine secretion causing cachexia of chronic inflammation

58
Q

TNF-β activity on Macrophages and PMN

A

Enhances phagocytic activity

59
Q

IL-4 target cell/tissue

A
  1. Antigen-primed B cells
  2. Activated B cells
60
Q

GM-CSF secreted by

A

Macrophages and Th cells

61
Q

IL-1 activty on NK cells

A

Enhance activity

62
Q

IL-1 target cells/tissue

A
  1. Th cells
  2. B cells
  3. NK cells
  4. Endothelial cells
  5. Macrophage and PMN
  6. Hepatocytes
  7. Hypothalamus
63
Q

IL-13 activity

A

Induces Isotype switch to IgE

64
Q

IL-11 secreted by

A

BM stroma

65
Q

Interferon-γ (type 2) target cell/tissue

A
  1. Macrophage
  2. All cell types
  3. Proliferating B cells
  4. Th2 cells
  5. Phagocytic cells
66
Q

Interferon-α (type 1) activity

A

Inhibits viral replication

67
Q

IL-10 activity

A

Suppressess cytokine production by Th1 cells

68
Q

Interferon-α clinical uses

A
  1. Hap B and C
  2. Leukemia
  3. Melanoma
69
Q

IL-10 target cell/tissue

A

Macrophages

70
Q

TGF-β target tissue/cells

A

Proliferating B cells

71
Q

IL-12 target tissue/cells

A
  1. Activated CD8
  2. NK and LAK cells
  3. Activated Th1
72
Q

IL-17 activity

A
  1. Increase inflammation
  2. Attract PMNs
  3. Induces IL-6, IL-1, TGFβ, TNFα, and IL-8
  4. Role in Autoimmune disease and Allergy
73
Q

Interferon-γ clinical use

A

CGD by increasing TNF

74
Q

IL-3 activity

A

Supports growth and differentiation of Myeloid cells

75
Q

Filgrastim

A

G-CSF analog

76
Q

IL-1 activity on Macrophages and PMN

A

Chemotactically attracts

77
Q

IL-7 activity

A

Induces differentiation into progenitor B and T cells

78
Q

Interferon-β (type 1) Secreted by

A

Fibroblasts

79
Q

GM-CSF target tissue/cell

A

BM granulocyte and macrophage precursors

80
Q

Interferon-α (type 1) secreted by

A

Leukocytes

81
Q

Interferon-γ (type 2) activity on proliferating B cells

A

Induces class swiching to IgG2a

Blocks IL-4 induced class swtiching to IgE and IgG1

Immunology (11 decks)

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