HS and Autoimmune

Question 1

Acute Rheumatic Fever Target antigen

Answer 1

Type 2 HS

Strep cell-wall Ag

Ab cross-reacts with myocardial AG

Question 2

Reiter’s Syndrome HLA allele

Answer 2

B27

Question 3

Guillain-Barre Syndrome specific pathogenic T cells

Answer 3

Peripheral nerve myelin or gangliosides

Question 4

SLE antigen involved

Answer 4

Type 3 HS

dsDNA

Sm

Question 5

Mast cell Mediators that are stored and released in response to Type 1 HS

Answer 5

1. Histamine
2. Heparin
3. Eosinophil Chemotactic factor A

Question 6

MS HLA allele

Answer 6

DR2

Question 7

Type 1 HS Tissue injury mechanism

Answer 7

Mast cells and their mediators

Question 8

Graves Disease HLA allele

Answer 8

B8

Question 9

Inflammatory Bowel Disease HLA allele

Answer 9

B27

Question 10

Ankylosing spondylitis HLA allele

Answer 10

B27

Question 11

Type 4 HS examples

Answer 11

1. MS
2. Hashimoto
3. RA
4. IDDM
5. Guillain-Barre (Ascending paralysis, peripheral nerve demyelination)
6. Celiac
7. Crohn

Question 12

Celiac HLA allele

Answer 12

DQ2 or DQ8

Question 13

Type 3 HS immune mechanism

Answer 13

Immune Complex Mediated

Immune complexes of circulating Ags and IgM or IgG Abs

Question 14

Psoriasis HLA allele

Answer 14

B27

Question 15

IDDM HLA allele

Answer 15

DR3/DR4

Question 16

Type 4 HS immune mechanism

Answer 16

1. CD4 TH1 and TH17 cells and their Cytokines
2. Cells of CMI that are stimulated

Question 17

Type 1 HS immune mechanism

Answer 17

IgE

Question 18

Rheumatoid Arthritis HLA allele

Answer 18

DR4

Question 19

Mast cell Mediators that are newly synthesized from Arachidonic acid in response to Type 1 HS

Answer 19

1. PGD₂
2. PGE₂
3. PGF_2α
4. Leukotrienes C₄, D₄, E₄
5. Leukotriene B₄

Question 20

SLE clinical manifestations

Answer 20

1. Nephritis
2. Arthritis
3. Vasculitis
4. Butterfly Facial Rash

Question 21

Goodpasture’s HLA allele

Answer 21

DR2

Question 22

PSGN clinical manifestations

Answer 22

Nephritis

Lumpy-Bumpy deposits

Question 23

PSGN antigen involved

Answer 23

Type 3 HS

Strep cell wall Ags

Question 24

Type 2 HS immune mechanism

Answer 24

Antibody-mediated

IgM and IgG Abs against cell or tissue Ags

Question 25

SLE HLA allele

Answer 25

DR2/DR3

Question 26

Effector cells of Type 1 HS

Answer 26

Mast cells Basophils Eosinophils

Question 27

Automimmune hemolytic anemia mechanism of pathogenesis

Answer 27

* Opsonization * Phagocytosis * Complement-mediated destruction of RBC

Question 28

Graves disease Target antigen

Answer 28

**Type 2 HS** TSH receptor

Question 29

Autoimmune Helolytic Anemia Target Antigen

Answer 29

**Type 2 HS** RBC membrane protein

Question 30

Prostaglandin effects

Answer 30

Increased smooth muscle contraction and vascular permeability

Question 31

Myasthenia gravis target antigen

Answer 31

**Type 2 HS** Ach receptor

Question 32

Histamine effect

Answer 32

* Smooth muscle contraction (**Bronchoconstriction, Intestinal hypermotility**) * Increased Vascular permeability

Question 33

Goodpasture Syndrome Target antigen

Answer 33

**Type 2 HS** Type 4 collagen in BM of kidney glomeruli and lung alveoli