Humor Effector

Question 1

What TH cells induce B-cell class switching

Answer 1

TH2

Question 2

Pepsin

Answer 2

Cleaves Ig to generate 1 large fragment called F(ab’)₂

Question 3

IgM Pentamer held together by

Answer 3

J Chain

Question 4

Thymus-independent antigens

Answer 4

Contain NO peptides

Stimulate only IgM

Create NO memory

Question 5

Classic pathway of complement

Answer 5

is activated by antigen-antibody complexes and is probably the more phylogenetically advanced system of activation

Question 6

IgA class switching occurs in

Answer 6

MALT

Tonsils

Peyer Patches

Question 7

Alternative pathway of complement activation

Answer 7

• It is initiated by simple attraction of the early factors to the surfaces of microbes
• Bacterial polysaccharides and the lipopolysaccharide of the cell envelope of Gram (-) bacterial both serve as potent initiating stimuli

Question 8

IgG job

Answer 8

1. Activates complements
2. Acts as an opsonin
3. Mediates ADCC

Question 9

Somatic hypermutation is

Answer 9

Random mutations in the coding of variable domain regions may occur when B-cells are undergoing intense proliferation

Question 10

What causes production of IgE

Answer 10

IL-4

Question 11

IgA found in

Answer 11

Mucosal surface of the body

An important component of breast milk

Question 12

What causes production of IgA

Answer 12

IL-5

Question 13

Papain causes

Answer 13

Ig cleavage above the disulfide bond that holds the heavy chains together generating 2 Fab and 1 Fc

Question 14

X-linked Hyper-IgM syndrome is due to

Answer 14

Defect in gene encoding CD40L