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Flashcards in Cytokines Deck (35)
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1

INF A and B target cells?

NK cells

2

INF Y produced by?

T helper cells

3

INF Y target

Macrophages, cytotoxic T cells, NK cells

4

INF A, B, Y Biologic activity?

Antiviral activity,
Mediates MHC class I amd II expression

5

TNF A produced by?

Macrophages, gram negative bacteria

6

TNF A target

Macrophages, mast cells

7

TNF A biologic activity

Mediates inflammation by recruiting and activating phagocytes

8

TNF B produced by?

Epithelial cells

9

TNF B target?

T Cells and B cells

10

Also known as lymphotoxin?

TNF B

11

IL-1 produced by

Monocytes, macrophges

12

IL-1 target

Hypothalamus, epithelial cells

13

IL-1 biologic actovity

Acute phase rections, mediate cell adhesion for diapedesis

14

IL-2 produced by

T helper cells

15

IL-2 target

Tcells and Bcells
Macrophages

16

IL-2 biologic actovity

Growth and differentiation of T cells and B cells, activtes monocytes, macrophages, and NK and cytotoxic cells

17

IL-4 produced by

Naive t cells and t helper cells

18

IL-4 target

T cells

19

IL-4 biologoc actovity

Induces growth of Thelper cells, mediates humoral immunity

20

IL-5 produced by

T helper cells

21

IL-5 target

Eosinophils, B cells

22

IL-5 biologic activity

Growth of eosinophils, mediator of type 1 hypersensitivoty reactions

23

IL -6 produced by

T cells, B cells, monocytes, macrophages, other nonimmune cells

24

IL-6 target

B cells, t cells

25

IL-6 biologic activity

Acute phase reactions, antibody production, stimulates B cells to plasma cells

26

IL-10 produced by

Monocytes, macrophages, T cells

27

IL-10 target

T helper cells, antigen precenting vells

28

IL-10 biologic activity

Antiinflammatory and suppresive effect

29

Transforming growth factor / TGF - B produced by?

T-regulatory cells

30

TGF -B target

T cells, B cells