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The removal of antibodies from serum by the addition of red cells that possess the corresponding surface antigen

Absorption

1

An antigen that is not genetically determined and is sometimes transient

Acquired antigen

2

Immunity that is generated by the actual production of antibody by the host in the presence of foreign antigen

Active immunity

3

Normal serum constituents that increase in the presence of infection, injury or trauma to the tissues

Acute phase proteins

4

A substance that can increase the specific antibody production to, or the degree of sensitization againts antigen by increasing the size or length of survival in the circulation. A substance (usually injected with an antigen) that improves the immune response, either humoral or cellular, to the antigen

Adjuvant

5

The attachment of one substance to the surfaceof another, in particular, the attachment of antibody to specific receptors on a cell surface

Adsorption

6

Collection into clamps of the cells or particles distributed in a fluid.

Agglutination

7

An antibody that is capable of causing agglutination with surface antigens

Agglutinin

8

An antigen agglutinated or clumped by an agglutinin

Agglutinogen

9

A system for activating complement beginning at C3 and do not involve a serologic reaction

Alternative complement pathway

10

A substance in the blood and the lymph serving as one of the active component on the process of cytolysis, the other components being the complement and the cells with antibodies. Anti-sheep red blood cell antibody that causes hemolysis of sheep red cells in the presence of complement.

Amboceptor

11

A globulin formed in response to exposure to an antigen. Also known as immunoglobulin

Antibody (Ab)

12

Any substance that oppose or counteract the action of a complement

Anticomplementary substance

13

Any substance which, when introduced into the body stimulates the formation of antibody

Antigen (Ag)

14

Union of antibody with its homologous antigen

Antigen-antibody complex

15

An autoantibody directed against a component of the nucleus, commonly found in systemic lupus erythematosus (SLE)

Antinuclear antibody (ANA)

16

A serum containing antibody

Antisera

17

An antibody produced against streptolysin O, a hemolysin produced by Group A streptococci.

Antistreptolysin O (ASO)

18

An antibody produced against "self" antigen

Autoantibody

19

A molecule that behaves as a "self" antigen

Autoantigen

20

A lymphocyte from the bursa of Fabricius or an immunoglobulin-forming cell

B-cell

21

A substance contained in beef erythrocytes, which is capable of absorbing the heterophil antibodies produced as a result of infectious mononucleosis (IM) and serum sickness.

Beef erythrocyte (BE) antigen

22

A protein, not normally present in human blood, appears in a wide variety of inflammatory conditions. It is characterized by their ability to react with the C-polysaccharide somatic substance of the pneumococci.

C-reactive protein

23

The majpr system of complement activation that involves all nine components of complement and is initiated by a serologic reaction

Classic component pathway

24

An agglutinin or hemagglutinin that is active at 4oC but not at 37oC

Cold agglutinin

25

A humoral mechanism of nonspecific immune response consisting of at least 14 components that proceed in a cascading sequence of activation resulting in cell lysis.

Complement

26

The fixation or binding of complement in a reaction with antigen and antibody

Complement fixation

27

Monitors day to day accurate performance of the lab tests/analyses

Control

28

A substance composed of extract from fresh beef hearts combined with lecithin and cholesterol

Cardiolipin antigen

29

A hemagglutination test that defines the characteristics of heterophil antibody by guinea pig and beef cell antigens

Davidsohn differential test

30

The most common procedure for the separation of mononuclear cells

Density gradient centrifugation

31

Theseparation of one substnce from theother

Dissociation

32

A fluid medium containing antibodies deliberately removed from thered cells

Eluate

33

A ligand assay in which the label is an enzyme and the binding reagent ks an antibody

Enzyme immunoassay

34

The point of dilution in a serologic reaction in which all the antigen and all the antibody are mutually involved in complexes

Equivalnce point

35

A specific type of precipitation that occurs over a narrow range of antigen concentration; aggregation pf colloidal particles in a serplogic reaction

Flocculation

36

A heteroplhil antibody that is stimulated by one antigen and reacts with unrelated surface antigen present on cells from dufferent mammalian species

Forssman antibody

37

A substance which absorbs the Forssman and serum sickness antibody

Guinea pig kidney (GPK) antigen

38

Flagellar ntigens of bacteria

H antigens

39

The agglutination or clumping of rbcs by the antiseru

Hemagglutination

40

Used inthe detection of antibodies involved in the blocking of agglutination of erythrocyrtes

Hemagglutination-inhibtion technique

41

Ruptured rbcs

Hemolyzed

42

A substance causing the agglutination of rbcs

Hemagglutinin

43

An ab capable of causing the lysis or dissolutuon of red cells with the consequent release of Hb

Hemolysin

44

The lysis of rbcs by specific antibody and serum complement

Hemolysis

45

Inflammation of liver caused by a virus or other agent (eg drugs)

Hepatitis

46

An ab produced in response to one Ntigen that will react with a second antigen genetically unrelated antigen

Heterophil antibody

47

An antigen that is broadly distributed in nature

Heterophil antigen

48

A virus that caused AIDS

Human immunodeficiency virus

49

A soln which has a concentration greater than the system woth which it is compared

Hypertonic solution

50

A process by which the activity of serum complement is nullified

Inactivation

51

An acite infectious disease caused by Epstein-Barr virus characterized by fever caharcterized by fever, pharyngitis and lymphadenopathy. There is a moderate leukocytosis due to abnormal mononuclear cells

Infectious mononucleosis (IM)

52

Outside the body; observable in a test tube

In-vitro

53

Within the living body

In-vivo

54

A molecule that combines with specific complementary configurations of the binding agent ( eg receptors, proteins, or antibody)

Ligand

55

The creation of a stable preparTion of a biologic material by rapid freezing and dehydration of the frozen produc under high vacuum

Lyophilization

56

An Ab which causes dissolution or lysis of cells

Lysin

57

An Ag-Ab reaction in which the reactive effect of a particular Ag is nullified by a specific Ab

Neutralization

58

The surface somatic Ag of bacteria

O Ag

59

An Ab that attaches to a cellular or particular Ag rendering it susceptible to phagocytosis

Opsonin

60

Hemagglutionation resulting from abs that are directed against ags absorbed to their rbc surface

Passive hemgglutination

61

The liquid portion of unclotted blood

Plasma

62

A weak or irregular ag-ab reaction occuring when a great excess of ag is exposed to a serum conataing a relatively low titer of ab

Postzone reaction

63

An ag-ab reaction in which a soluble ag is caused to settle out by the action of specific ab (precipitin)

Precipitation

64

A negative or weak reaction occurring when serum containing an extremely high titer of ab is exposed to a relativly small amoung of ag. The failure of a serologic reaction to occur in a high concentration of ab.

Prozone reaction

65

The clumping of cells caused by agents other than abs.

Pseudoagglutination

66

An atom with an unstable nucleus that spontaneously emits rediatin as it decays to a stable nucleus.

Radioisotope

67

An ab-like substance produced by the body in response to certain types of tissue invasion and destruction. It is found in varying small amounts normally, but is usally increased in syphilis, malaria and certain other diseases.

Reagin

68

A progressively higher dissolution of a substance arranged in a definite sequence or series.

Serial dilution

69

A brance of biology which concerns itself with ags and abs and their relationships

Serology

70

A condition wherein the cells are coated with incomplete (blocking or univalent) specific ab.

Sensitized

71

Thedetection of a specific ab in the serum of an individual in whom the ab was previously undetectable

Seroconversion

72

The fluid portion after the blood clots

Serum

73

The special affinity between the ag and its corresponding ab

Specificity

74

An assay in Which one of the reactants is bound to a surface

Solid radioimmunoassay

75

An enzyme that dissolves clots by converting plasminogen to plasmin

Streptokinase

76

A thymus derived lymphocyte responsible for cell-mediated hypersensitivity

T-lymphocyte (T-cell)

77

An expression of the highest dilution of serum which gives a visible reaction

Titer

78

The measurement of light transmitted through a suspension of particles

Turbidimetry

79

The agglutination of rbcs by a virus

Viral hemagglutination

80

An ab (or agglutinin) or hemagglutinin that is active at 37oC but not at 4oC

Warm agglutinin

81

The reduction in electrical charge of a red cell when it is suspended in a high ionic strength colloidal medium ( albumin)

Zeta potential