Flashcards in Glossary Deck (82):
The removal of antibodies from serum by the addition of red cells that possess the corresponding surface antigen
An antigen that is not genetically determined and is sometimes transient
Immunity that is generated by the actual production of antibody by the host in the presence of foreign antigen
Normal serum constituents that increase in the presence of infection, injury or trauma to the tissues
Acute phase proteins
A substance that can increase the specific antibody production to, or the degree of sensitization againts antigen by increasing the size or length of survival in the circulation. A substance (usually injected with an antigen) that improves the immune response, either humoral or cellular, to the antigen
The attachment of one substance to the surfaceof another, in particular, the attachment of antibody to specific receptors on a cell surface
Collection into clamps of the cells or particles distributed in a fluid.
An antibody that is capable of causing agglutination with surface antigens
An antigen agglutinated or clumped by an agglutinin
A system for activating complement beginning at C3 and do not involve a serologic reaction
Alternative complement pathway
A substance in the blood and the lymph serving as one of the active component on the process of cytolysis, the other components being the complement and the cells with antibodies. Anti-sheep red blood cell antibody that causes hemolysis of sheep red cells in the presence of complement.
A globulin formed in response to exposure to an antigen. Also known as immunoglobulin
Any substance that oppose or counteract the action of a complement
Any substance which, when introduced into the body stimulates the formation of antibody
Union of antibody with its homologous antigen
An autoantibody directed against a component of the nucleus, commonly found in systemic lupus erythematosus (SLE)
Antinuclear antibody (ANA)
A serum containing antibody
An antibody produced against streptolysin O, a hemolysin produced by Group A streptococci.
Antistreptolysin O (ASO)
An antibody produced against "self" antigen
A molecule that behaves as a "self" antigen
A lymphocyte from the bursa of Fabricius or an immunoglobulin-forming cell
A substance contained in beef erythrocytes, which is capable of absorbing the heterophil antibodies produced as a result of infectious mononucleosis (IM) and serum sickness.
Beef erythrocyte (BE) antigen
A protein, not normally present in human blood, appears in a wide variety of inflammatory conditions. It is characterized by their ability to react with the C-polysaccharide somatic substance of the pneumococci.
The majpr system of complement activation that involves all nine components of complement and is initiated by a serologic reaction
Classic component pathway
An agglutinin or hemagglutinin that is active at 4oC but not at 37oC
A humoral mechanism of nonspecific immune response consisting of at least 14 components that proceed in a cascading sequence of activation resulting in cell lysis.
The fixation or binding of complement in a reaction with antigen and antibody
Monitors day to day accurate performance of the lab tests/analyses
A substance composed of extract from fresh beef hearts combined with lecithin and cholesterol
A hemagglutination test that defines the characteristics of heterophil antibody by guinea pig and beef cell antigens
Davidsohn differential test
The most common procedure for the separation of mononuclear cells
Density gradient centrifugation
Theseparation of one substnce from theother
A fluid medium containing antibodies deliberately removed from thered cells
A ligand assay in which the label is an enzyme and the binding reagent ks an antibody
The point of dilution in a serologic reaction in which all the antigen and all the antibody are mutually involved in complexes
A specific type of precipitation that occurs over a narrow range of antigen concentration; aggregation pf colloidal particles in a serplogic reaction
A heteroplhil antibody that is stimulated by one antigen and reacts with unrelated surface antigen present on cells from dufferent mammalian species
A substance which absorbs the Forssman and serum sickness antibody
Guinea pig kidney (GPK) antigen
Flagellar ntigens of bacteria
The agglutination or clumping of rbcs by the antiseru
Used inthe detection of antibodies involved in the blocking of agglutination of erythrocyrtes
A substance causing the agglutination of rbcs
An ab capable of causing the lysis or dissolutuon of red cells with the consequent release of Hb
The lysis of rbcs by specific antibody and serum complement
Inflammation of liver caused by a virus or other agent (eg drugs)
An ab produced in response to one Ntigen that will react with a second antigen genetically unrelated antigen
An antigen that is broadly distributed in nature
A virus that caused AIDS
Human immunodeficiency virus
A soln which has a concentration greater than the system woth which it is compared
A process by which the activity of serum complement is nullified
An acite infectious disease caused by Epstein-Barr virus characterized by fever caharcterized by fever, pharyngitis and lymphadenopathy. There is a moderate leukocytosis due to abnormal mononuclear cells
Infectious mononucleosis (IM)
Outside the body; observable in a test tube
Within the living body
A molecule that combines with specific complementary configurations of the binding agent ( eg receptors, proteins, or antibody)
The creation of a stable preparTion of a biologic material by rapid freezing and dehydration of the frozen produc under high vacuum
An Ab which causes dissolution or lysis of cells
An Ag-Ab reaction in which the reactive effect of a particular Ag is nullified by a specific Ab
The surface somatic Ag of bacteria
An Ab that attaches to a cellular or particular Ag rendering it susceptible to phagocytosis
Hemagglutionation resulting from abs that are directed against ags absorbed to their rbc surface
The liquid portion of unclotted blood
A weak or irregular ag-ab reaction occuring when a great excess of ag is exposed to a serum conataing a relatively low titer of ab
An ag-ab reaction in which a soluble ag is caused to settle out by the action of specific ab (precipitin)
A negative or weak reaction occurring when serum containing an extremely high titer of ab is exposed to a relativly small amoung of ag. The failure of a serologic reaction to occur in a high concentration of ab.
The clumping of cells caused by agents other than abs.
An atom with an unstable nucleus that spontaneously emits rediatin as it decays to a stable nucleus.
An ab-like substance produced by the body in response to certain types of tissue invasion and destruction. It is found in varying small amounts normally, but is usally increased in syphilis, malaria and certain other diseases.
A progressively higher dissolution of a substance arranged in a definite sequence or series.
A brance of biology which concerns itself with ags and abs and their relationships
A condition wherein the cells are coated with incomplete (blocking or univalent) specific ab.
Thedetection of a specific ab in the serum of an individual in whom the ab was previously undetectable
The fluid portion after the blood clots
The special affinity between the ag and its corresponding ab
An assay in Which one of the reactants is bound to a surface
An enzyme that dissolves clots by converting plasminogen to plasmin
A thymus derived lymphocyte responsible for cell-mediated hypersensitivity
An expression of the highest dilution of serum which gives a visible reaction
The measurement of light transmitted through a suspension of particles
The agglutination of rbcs by a virus
An ab (or agglutinin) or hemagglutinin that is active at 37oC but not at 4oC