Cytokines, Interferons, Cell Surface Molecules II Flashcards Preview

Immunology > Cytokines, Interferons, Cell Surface Molecules II > Flashcards

Flashcards in Cytokines, Interferons, Cell Surface Molecules II Deck (26)
1

What CD markers are ubiquitous to all cells?

CD54, CD58

2

What CD marker is expressed exclusively by NK cells?

CD56

3

What CD cell type mediated leukocyte adhesion and rolling interaction with the endothelium?

CD82L

4

Which cell types possess CD82L?

B cells, T cells, monocytes, NK cells.

5

What CD cell type is a high affinity receptor for IgG?

CD64

6

What CD cell type is a receptor for IgA?

CD89

7

What CD cell type is ubiquitous to all proliferating (i.e. activated cells)?

CD71

8

What CD cell type is unique to lymphocytes?

CD81

9

What type of cells express CD80 antigens?

B cells.

10

What cell marker is used to count T cells?

CD3

11

What cell markers are used to count B cells?

Membrane bound IgM, CD19, CD20.

12

A deficiency in what CD cell type is associated with Leukocyte Adhesion Deficiency?

CD18 integrin.

13

What important cytokines are secreted by macrophages?

IL-1, IL-6, IL-8, IL-12, TNFa (p.200)

14

Name four functions of IL-1.

1.) endogenous pyrogen- causes fever; 2.) causes acute inflammation; 3.) activates endothelium to express adhesion molecules; 4.) induces chemokine secretion to recruit leukocytes (p.200)

15

What is the function of IL-6?

An endogenous pyrogen that causes fever and stimulates production of acute phase proteins (p.200)

16

What cell type secretes IL-6?

Th2 cells (p.200)

17

Describe the principle functions of cytokines IL-1 through IL-5.

(Hot T-Bone stEAk) IL-1: fever (hot); IL-2: stimulates T cells; IL-3: stimulates Bone marrow; IL-4: stimulates IgE production; IL-5: stimulates IgA production (p.200)

18

What is the major function of IL-8?

IL-8 is the major chemotactic factor for neutrophils; IL-8 helps clear infections (p.200)

19

What are the two major functions of IL-12?

To induce differentiation of T cells into Th1 cells and to activate NK cells (p.200)

20

What cell type secretes IL-12?

IL-12 is secreted by B cells (p.200)

21

What are the four major functions of TNF-a?

Mediation of septic shock, activation of endothelium, leukocyte recruitment, vascular leak (p.200)

22

What two cytokines are secreted by all T cells?

IL-2 and IL-3 (p.200)

23

From where is IFN-y secreted?

From Th1 cells (p.200)

24

What is secreted from Th2 cells?

IL-4, IL-5, IL-10, IL-13 (p.200)

25

What is the function of IL-2?

Stimulates growth of helper, cytotoxic, and regulatory T cells (p.200)

26

What is the function of IL-3?

Supports the growth and differentiation of bone marrow stem cells. Functions like GM-CSF (p.200)