Cytokines of Adaptive Immunity Flashcards Preview

MSS-IHL Final Exam > Cytokines of Adaptive Immunity > Flashcards

Flashcards in Cytokines of Adaptive Immunity Deck (24):
1

IL-2

mediates growth, survival, and differentiate of T lymphocytes

2

activity of IL-2

anti-apoptotic function to promote survival
-BCL-2

also promotes cell cycle through cyclin synthesis
-p27 degradation

3

regulatory T cells and IL-2

regulatory T cells suppress autoreactivity and inhibit the T cell response (inhibitory)

-IL-2 is require for their survival
receptor is constitutively expressed**

4

NK cells and IL-2

will stimulate their differentiation

5

IL2 and B cells?

stimulate antibody production

6

source of IL-2

mainly produced by CD4+ T cells
-activated by antigens and costimulators

secreted into the synapse between T cell and APC

7

IL-4

signature cytokine of Th2 cells
-stimulates differention of CD4+ Th2 cells
-inhibits the differentiate of Th1

activate mast cell/eosinophil mediated reactions

8

IL-4 on B cells?

will stimulate them to produce IgE
-IgE is parasitic response and allergies

9

IL-4 and macrophages?

induces arginase expression that leads to collagen production and fibrosis (alternative pathway of macrophage activation)

10

IL-5

activator of eosinophils
-Th2 release

stimulates growth and differentiate of eosinophils

also stimulates B cells to proliferate IgA (mucosal)

11

sources of IL-5

Th2 cells **
also activated mast cells

-acts to activate eosinophils
kills helminthes
IgG and IgA

12

IL-13

produced by Th2 CD4+ T cells**
-also produced by NK cells in early phase allergic response or basophils or eosinophils
shared effects with IL-4

13

IL-13 receptor expression?

B cells, mononuclear phagocytes, dendritic cells, eosinophils, basophils, fibroblasts, endothelial cells

14

Th1 and Th2 and endothelial cells?

can both induce extravasation

15

IL-13 clinical application?

promotes fibrosis (through arginase - decreased NO)
induces TGF-beta (promotes fibrosis

IL-13 contributes to pathology of chronic asthma

induces mucus production, IgE class switching, inflammation

16

IFN gamma

Th1 release

activates macrophages
-stimulate them to kill phagocytosed microbes
-increase ROS and NO production


17

signal from T cells for IFN gamma?

via T cells - CD40 and IFN-gamma
via NK cells - IFN-gamma alone

18

activity of IFN-gamma

promotes Th1 and inhibits Th2 (with IL-12)

promotes B cells to switch to IgG

19

activity of IFN-gamma on APCs?

induces MHC I and II, costimulators and transporters and proteosome

20

source of IFN-gamma

NK cells
Th1 cells
CD8+ T cells

21

TGF-beta

inhibits proliferation of lymphocytes and leukocytes
conteracts effects of inflammatory cytokines

stimulates B cells to produce IgA
-mucosal immunity

stimulates healing
-fibroblasts and macrophages
-collagen synthesis and matrix remodeling

produced by T cells, LPS-activated phagocytes, and regulatory T cells

22

what cell type is responsible for the deposition of collagen?

macrophages (resident)

23

stimulation of fibrosis?

initial infection usually cleared by Th1 response

if it doesn't clear, goes to Th2 response
-fibrotic response by macrophages and fibroblasts

24

cause of allergic asthma?

stimulus seen as a persistent infectious agent
-transition to Th2 response
-tissue lacks Th1 response

secondary stimulus exacerbates the fibrotic response