Flashcards in Cytokines of Adaptive Immunity Deck (24):
mediates growth, survival, and differentiate of T lymphocytes
activity of IL-2
anti-apoptotic function to promote survival
also promotes cell cycle through cyclin synthesis
regulatory T cells and IL-2
regulatory T cells suppress autoreactivity and inhibit the T cell response (inhibitory)
-IL-2 is require for their survival
receptor is constitutively expressed**
NK cells and IL-2
will stimulate their differentiation
IL2 and B cells?
stimulate antibody production
source of IL-2
mainly produced by CD4+ T cells
-activated by antigens and costimulators
secreted into the synapse between T cell and APC
signature cytokine of Th2 cells
-stimulates differention of CD4+ Th2 cells
-inhibits the differentiate of Th1
activate mast cell/eosinophil mediated reactions
IL-4 on B cells?
will stimulate them to produce IgE
-IgE is parasitic response and allergies
IL-4 and macrophages?
induces arginase expression that leads to collagen production and fibrosis (alternative pathway of macrophage activation)
activator of eosinophils
stimulates growth and differentiate of eosinophils
also stimulates B cells to proliferate IgA (mucosal)
sources of IL-5
Th2 cells **
also activated mast cells
-acts to activate eosinophils
IgG and IgA
produced by Th2 CD4+ T cells**
-also produced by NK cells in early phase allergic response or basophils or eosinophils
shared effects with IL-4
IL-13 receptor expression?
B cells, mononuclear phagocytes, dendritic cells, eosinophils, basophils, fibroblasts, endothelial cells
Th1 and Th2 and endothelial cells?
can both induce extravasation
IL-13 clinical application?
promotes fibrosis (through arginase - decreased NO)
induces TGF-beta (promotes fibrosis
IL-13 contributes to pathology of chronic asthma
induces mucus production, IgE class switching, inflammation
-stimulate them to kill phagocytosed microbes
-increase ROS and NO production
signal from T cells for IFN gamma?
via T cells - CD40 and IFN-gamma
via NK cells - IFN-gamma alone
activity of IFN-gamma
promotes Th1 and inhibits Th2 (with IL-12)
promotes B cells to switch to IgG
activity of IFN-gamma on APCs?
induces MHC I and II, costimulators and transporters and proteosome
source of IFN-gamma
CD8+ T cells
inhibits proliferation of lymphocytes and leukocytes
conteracts effects of inflammatory cytokines
stimulates B cells to produce IgA
-fibroblasts and macrophages
-collagen synthesis and matrix remodeling
produced by T cells, LPS-activated phagocytes, and regulatory T cells
what cell type is responsible for the deposition of collagen?
stimulation of fibrosis?
initial infection usually cleared by Th1 response
if it doesn't clear, goes to Th2 response
-fibrotic response by macrophages and fibroblasts