T Cell Interactions Flashcards Preview

MSS-IHL Final Exam > T Cell Interactions > Flashcards

Flashcards in T Cell Interactions Deck (25):
1

which cell type is responsible for eliminating viral infections?

CD8+ T cells

2

deficiency in expression of what HLA would lead to deficiency of CD8+ T cells?

HLA A, B, or C

-bc ABC are type I HLA (CD8)

3

what process would be interrupted in CD8 deficiency?

no positive selection for the T cells

4

what would lead to high IgG levels?

chronic infection

5

class I HLA deficiency?

lack of CD8+ T cells

recessive disorder

nonsense mutations in the TAP2 gene

6

acute infectious mononucleosis?

spread through saliva
-IgM and IgG antibodies against EBV capsid antigen

7

heterophile antibodies

produced against poorly defined antigens

8

what does IgG indicate?

prior infection occured

9

what are protective against recurrent infections?

IgG - secondary response

IgM - primary response

10

what happens to kill viruses?

granzyme and perforin release

11

what is inhibited during immunosuppression?

T cell response

12

umbilical cord blood transformation of B cells vs. adult ?

most adults harbor T cells specific for EBV
-infants don't have these T cells

T cells inhibit the B cell transformation
-it kills the B cells that express antigen
-so its easier in infants

13

why are males with X-linked agammaglobulinemia (XLA) unable to be infected with EBV?

EBV is specific for B cells

so if you don't got B cells, you don't got EBV!

BUT, T cells are necessary to control EBV infection

14

bacteria causing leprosy?

mycobacterium leprae

15

mycobacterium leprae

involved in leprosy

16

what is best treatment for lepromatous leprosy?

if its disseminated - you have a Th2 dominant response
-spreading bc can't contain it

treat with IFN-gamma (Th1 response)

17

why would an individual with lepromatous leprosy have hypergammaglobulinemia?

upregulated Th2 response would cause increased antibody production

18

mycobacterium leprae with a Th1 response?

tuberculoid leprosy

19

mycobacterium leprae with a Th2 response?

lepromatous leprosy

20

staphylococcus?

superantigen

21

what cytokine would be responsible for vascular depletion observed after superantigen infection?

TNF-alpha

secreted by T helper cells CD4

22

what do the superantigens activate?

V-beta region of T cell

absence of co-receptors and co-stimulation

very rapid response
cannot protect using memory immunity bc superantigens have no antigenic epitopes

**will suppress T cell responses
cytokine storm!

23

what is DTH response associated with?

granuloma formation

24

IFN-gamma receptor deficiency?

no macrophage response

25

IFN-gamma deficiency similar to what?

IL-12 deficiency