Humoral Immunity Flashcards Preview

MSS-IHL Final Exam > Humoral Immunity > Flashcards

Flashcards in Humoral Immunity Deck (18):
1

humoral immunity

defense against extracellular pathogens

mediated by B cells

2

plasma cells

produce antibodies in lymph tissues/organs

antibodies perform function at sites distant from production

3

effector function of antibodies?

neutralization, opsonization, and complement activation

4

neutralization

antibody binds to pathogen so it can't gain entry to cell

sterically hinders the pathogens

**only requires binding to antigen

5

opsonization

microbe that is crosslinked with IgG
-phagocyte binds the Fc-gamma-RI receptors and activate it to ingest an kill pathogen

6

ADCC

antigen-dependent cellular cytotoxicity

NK binds to antibody-coated cells by Fc receptor and destroy these cells

7

mucosal immunity

IgA is secreted

**very important

8

neonatal immunity

antibody transport across the placenta and ingested in breast milk

IgG FcRn - transports across placenta
IgA in breat milk

9

what Abs for complement activation?

IgG and IgM

10

why is IgG so much more protective than IgM

IgM can only activate complement
IgG can activate phagocytosis and complement
-IgG also activates NK cells

11

CD19+ population?

B cells

12

CD3+ populaiton?

pan T cell marker

13

hyper IgM immunodeficiency

inability to class switch**
aka HIGM

five genetic types

prone to bacterial and opportunistic infections
neutropenia, failure to thrive, thrombocytopenia, and anemia are common

14

X-linked HIGM?

defective CD40L expression

15

why are there antibodies to blood group antigens but not to tetanus toxoid antigens?

blood antigens - sugars
-t independent only produce IgM

tetanus - proteins

16

IVIG

pooled human immunoglobulins
-treatment for autoimmune/inflammatory diseases

though to engage inhibitory FcR on B cells (inflammatory)

also used to provide Igs (autoimmune)

17

cryoglobulinemia

chronic infection can lead to immune complex disease

-requires persistent immune response

immune complexes may become immunogenic
-IgM made against IgG

mechanism unknown

presence of ICs in kidneys, small blood vessels, and other organs

18

why would monoclonal antibody against CD20 help cryoglobulinemia patients

CD20 pan-B cell marker

would target B cells for death - no antibody problem